Defining a new player in atherosclerosis: The role of Adventitial Haemangioblasts as an "outside-in" driver of plaque growth and stability.

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As the underlying cause of heart attack, atherosclerosis is a leading cause of death worldwide. New approaches to treatment are desperately needed and this requires a better understanding of how atherosclerotic plaques form in arteries. This project studies a new population of stem cells that we have discovered in the outer layer of arteries, to determine how they cause plaques to form, so that we can develop new therapies that target these stem cells to more effectively treat atherosclerosis.