ROLE OF MONOCYTES IN AIDS AND AS TARGETS FOR ANTIVIRAL THERAPY

单核巨噬细胞是HIV-1的重要宿主，在 病毒的传播和艾滋病的发病机制。这些研究 关注艾滋病患者单核吞噬细胞功能的改变 患者和HIV-1感染后的体外实验。大量的表型和 已经定义了功能异常。例如，细胞中的单核细胞 正常人循环不表达Fc(Gamma)R111，而 许多艾滋病单核细胞Fc(γ)RIII呈阳性。这一点的升级 调节免疫吞噬和有毒氧释放的受体 物种可能与循环中的转化生长因子-β水平升高有关。 转化生长因子-β也是一种有效的免疫抑制剂，由艾滋病毒产生。 感染的单核细胞。基于越来越多的证据表明单核细胞 作为艾滋病进化的核心，研究也针对探索 针对单核细胞人群的潜在抗病毒疗法。 除了循环中的单核细胞外，艾滋病毒在中国也是高发的 组织巨噬细胞。胃肠道是进入人体的主要途径。 一系列的研究都集中在免疫学和 人类免疫缺陷病毒口腔和口腔感染的临床表现 胃肠道。

Monocyte-macrophages are important hosts for HIV-1, playing key roles in the dissemination of the virus and the pathogenesis of AIDS. These studies focus on defining altered functions of mononuclear phagocytes from AIDS patients and following HIV-1 infection in vitro. Numerous phenotypic and functional abnormalities have been defined. For example, monocytes in the circulation of normal individuals do not express Fc(gamma)R111, whereas many AIDS monocytes are FC(gamma)RIII positive. Upregulation of this receptor which modulates immunophagocytosis and release of toxic oxygen species may be related to increased circulating levels of TGF-beta. TGF-beta is also a potent immunosuppressive agent and is produced by HIV infected monocytes. Based on the emerging evidence that monocytes are central to the evolution of AIDS, studies are also directed at exploring potential antiviral therapies targeted at the monocyte population. In addition to circulating monocytes, HIV is found in high frequency in tissue macrophages. The gastrointestinal tract is a major route of entry for HIV and a series of studies are focusing on the immunologic and clinical manifestations of HIV infection of the oral cavity and gastrointestinal tract.