BIOCHEMICAL EVALUATION OF ADRENERGIC FUNCTION--RESPONSES TO STRESS & DISEASE

肾上腺素能功能的生化评估——对压力的反应

基本信息

项目摘要

The main objectives of this project are (1) to determine the physiologic significance of alterations in plasma levels and urinary excretion rates of the catecholamines, their metabolites and their precursor, DOPA; (2) to develop in animals and humans clinically useful methods for assessing catecholaminergic function; and (3) to apply these methods to examine function of catecholaminergic neurons in the peripheral sympathetic nervous system and in brain. Changes in tissue or plasma levels or urinary excretion rates of catecholamines and their metabolites, and tissue tyrosine hydroxylase levels are evaluated, during and after stress, in response to pharmacologic treatments, or in disease states in animals, in normal subjects, and in patients with various neurologic or related disorders (autonomic dysfunction, Parkinson's disease, hypertension, etc). Use of 18-F labelled dopamine has been developed for imaging by positron emission tomography (PET) peripheral sympathetic activity in vivo in dogs and is awaiting application to humans. In rats, plasma levels of DOPA parallel pharmacologic or stress-induced enhancement of norepinephrine release, even after adrenalmedullectomy. Tyrosine hydroxylase levels in tissues do not reflect the rate of catecholamine production, indicating that tyrosine hydroxylation, can be regulated independently of the levels of tyrosine hydroxylase. Chronic elevation of plasma glucocorticoid levels elevates rat blood pressure but depresses plasma norepinephrine levels. Baroreceptor sensitivity is unaltered and pressor responses to phenylephrine are normal. There is, however, an increase in the tachycardia induced by isoproterenol, indicating that cardiac beta-adrenoceptors are hyperresponsive. The mechanism of hypertension attending chronic elevation of corticosteriods differs from that in other forms of hypertension. Most patients with pure autonomic failure were found to have low plasma levels of DOPA as well as of norepinephrine, DHPG and DOPAC, consistent with loss of peripheral sympathetic neurons, whereas in most patients with multiple system atrophy, levels of DOPA, DHPG and DOPAC are generally normal; this is consistent with normal catecholamine biosynthesis in these patients who are believed to have intact peripheral sympathetic neurons but diminished nerve impulse traffic from the central nervous system.
本课题的主要目的是(1)确定生理

项目成果

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I J KOPIN其他文献

I J KOPIN的其他文献

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{{ truncateString('I J KOPIN', 18)}}的其他基金

REGULATION OF PERIPHERAL AUTONOMIC FUNCTION AND NEUROENDOCRINE RESPONSES
末梢自主功能和神经内分泌反应的调节
  • 批准号:
    2579634
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOCHEMICAL EVALUATION OF ADRENERGIC FUNCTION
肾上腺素能功能的生化评价
  • 批准号:
    3922601
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BRAIN AMINES--REGULATION AND FUNCTION
脑胺——调节和功能
  • 批准号:
    3846346
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
REGULATION OF PERIPHERAL AUTONOMIC FUNCTION AND NEUROENDOCRINE RESPONSES
末梢自主功能和神经内分泌反应的调节
  • 批准号:
    6163075
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOCHEMICAL EVALUATION OF ADRENERGIC FUNCTION
肾上腺素能功能的生化评价
  • 批准号:
    3945312
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOCHEMICAL EVALUATION OF ADRENERGIC FUNCTION
肾上腺素能功能的生化评价
  • 批准号:
    3969091
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BRAIN AMINES--REGULATION AND FUNCTION
脑胺——调节和功能
  • 批准号:
    3760348
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MPTP TOXICITY AND ANIMAL MODELS OF PARKINSON'S DISEASE
MPTP 毒性和帕金森病动物模型
  • 批准号:
    3945311
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BRAIN AMINES--REGULATION AND FUNCTION
脑胺——调节和功能
  • 批准号:
    3782454
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOCHEMICAL EVALUATION OF AMINERGIC FUNCTION DURING RESPONSES TO STRESS & DISEASE
应激反应过程中胺能功能的生化评估
  • 批准号:
    3860836
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Pre and post-synaptic pathways underlying the stress response in the adrenal medulla
肾上腺髓质应激反应的突触前和突触后通路
  • 批准号:
    10609941
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肾上腺髓质应激反应的突触前和突触后通路
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    10207848
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    2015
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Identifying a role of delta-5 steroids from adrenal cortex for development of adrenal medulla
确定肾上腺皮质 delta-5 类固醇对肾上腺髓质发育的作用
  • 批准号:
    25860764
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Roles for PPAR gamma in the hypothalamic PVN in the catecholamin secretion from adrenal medulla in rats
下丘脑 PVN 中 PPAR γ 在大鼠肾上腺髓质分泌儿茶酚胺中的作用
  • 批准号:
    24590903
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    2012
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Chromaffin progenitor cells from the adrenal medulla (A06)
来自肾上腺髓质的嗜铬祖细胞 (A06)
  • 批准号:
    12489121
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    2005
  • 资助金额:
    --
  • 项目类别:
    Collaborative Research Centres
Mechanisms of the adrenal medulla stress response.
肾上腺髓质应激反应的机制。
  • 批准号:
    7354095
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
Mechanisms of the adrenal medulla stress response
肾上腺髓质应激反应的机制
  • 批准号:
    6910550
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    2005
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Mechanisms of the adrenal medulla stress response.
肾上腺髓质应激反应的机制。
  • 批准号:
    7009604
  • 财政年份:
    2005
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Mechanisms of the adrenal medulla stress response.
肾上腺髓质应激反应的机制。
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    7195829
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    2005
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