BIOCHEMICAL EVALUATION OF ADRENERGIC FUNCTION--RESPONSES TO STRESS & DISEASE
肾上腺素能功能的生化评估——对压力的反应
基本信息
- 批准号:3881771
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Pongidae adrenal medulla aminoacid biosynthesis catecholamines cerebrospinal fluid desipramine dihydroxyphenylalanine dopamine epididymis epinephrine homovanillate laboratory rat neuropharmacology neurotransmitter metabolism norepinephrine peripheral nervous system plasma positron emission tomography psychological stressor radiotracer spinal cord stress sympathetic nervous system synapses tyrosine 3 monooxygenase urinalysis
项目摘要
The main objectives of this project are (1) to determine the physiologic
significance of alterations in plasma levels and urinary excretion rates of
the catecholamines, their metabolites and their precursor, DOPA; (2) to
develop in animals and humans clinically useful methods for assessing
catecholaminergic function; and (3) to apply these methods to examine
function of catecholaminergic neurons in the peripheral sympathetic nervous
system and in brain.
Changes in tissue or plasma levels or urinary excretion rates of
catecholamines and their metabolites, and tissue tyrosine hydroxylase
levels are evaluated, during and after stress, in response to pharmacologic
treatments, or in disease states in animals, in normal subjects, and in
patients with various neurologic or related disorders (autonomic
dysfunction, Parkinson's disease, hypertension, etc). Use of 18-F labelled
dopamine has been developed for imaging by positron emission tomography
(PET) peripheral sympathetic activity in vivo in dogs and is awaiting
application to humans.
In rats, plasma levels of DOPA parallel pharmacologic or stress-induced
enhancement of norepinephrine release, even after adrenalmedullectomy.
Tyrosine hydroxylase levels in tissues do not reflect the rate of
catecholamine production, indicating that tyrosine hydroxylation, can be
regulated independently of the levels of tyrosine hydroxylase. Chronic
elevation of plasma glucocorticoid levels elevates rat blood pressure but
depresses plasma norepinephrine levels. Baroreceptor sensitivity is
unaltered and pressor responses to phenylephrine are normal. There is,
however, an increase in the tachycardia induced by isoproterenol,
indicating that cardiac beta-adrenoceptors are hyperresponsive. The
mechanism of hypertension attending chronic elevation of corticosteriods
differs from that in other forms of hypertension.
Most patients with pure autonomic failure were found to have low plasma
levels of DOPA as well as of norepinephrine, DHPG and DOPAC, consistent
with loss of peripheral sympathetic neurons, whereas in most patients with
multiple system atrophy, levels of DOPA, DHPG and DOPAC are generally
normal; this is consistent with normal catecholamine biosynthesis in these
patients who are believed to have intact peripheral sympathetic neurons but
diminished nerve impulse traffic from the central nervous system.
本课题的主要目的是(1)确定生理
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('I J KOPIN', 18)}}的其他基金
REGULATION OF PERIPHERAL AUTONOMIC FUNCTION AND NEUROENDOCRINE RESPONSES
末梢自主功能和神经内分泌反应的调节
- 批准号:
2579634 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF PERIPHERAL AUTONOMIC FUNCTION AND NEUROENDOCRINE RESPONSES
末梢自主功能和神经内分泌反应的调节
- 批准号:
6163075 - 财政年份:
- 资助金额:
-- - 项目类别:
MPTP TOXICITY AND ANIMAL MODELS OF PARKINSON'S DISEASE
MPTP 毒性和帕金森病动物模型
- 批准号:
3945311 - 财政年份:
- 资助金额:
-- - 项目类别:
BIOCHEMICAL EVALUATION OF AMINERGIC FUNCTION DURING RESPONSES TO STRESS & DISEASE
应激反应过程中胺能功能的生化评估
- 批准号:
3860836 - 财政年份:
- 资助金额:
-- - 项目类别:
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