ALZHEIMER'S DISEASE CENTER CORE GRANT

阿尔茨海默病中心核心拨款

• 批准号: 3100940
• 负责人: LEONARD T KURLAND
• 金额: $ 29.56万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-15 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3100940
• 关键词: Alzheimer's disease; biomedical facility

The proposed Mayo Clinic Alzheimer's Disease Research Center (ADRC) is designed to be a major patient evaluation, research, and education resource for the upper Midwest. Epidemiology studies utilizing the population data base at the Mayo Clinic have provided the first age- and sex-specific incidence rates in the United States for dementing illnesses. The Mayo Clinic ADRC will extend these epidemiologic studies through a prospective community survey to establish prevalence rates in the urban and rural populations of Olmsted County, Minnesota. Case/control studies have been designed to evaluate etiologic risk factors including familial aggregation, environmental, and occupational toxic exposures. In the course of the community survey, a large number of non-demented elderly subjects will be identified, and normative values for commonly used neuropsychological tests for the elderly and the very elderly (80 and over) will be established. A unique feature of this ADRC is its ability to compare a community based population with a referral population with respect to demographic and clinical characteristics as well as survivorship. A neuropharmacology research project will study muscarinic acetylcholine receptor subtypes in Alzheimer's disease. A neuroimaging project will correlate volumetric changes in medial temporal lobe structures as measured by magnetic resonance imaging and functional changes as measured by single photon emission computed tomography with neuropsychological, clinical, and demographic characteristics of Alzheimer's disease patients and normal controls in a longitudinal fashion. The primary focus of the proposed ADRC in the initial years will be to establish a regional referral center for patients with Alzheimer's disease. The Mayo clinic is expanding its commitment to alzheimer's disease research by establishing an Alzheimer's disease research facility as part of its Jacksonville, Florida, clinic. It is anticipated that the proposed ADRC will expand to encompass the Jacksonville activities in future years.

拟议中的马约诊所阿尔茨海默病研究中心（ADRC）是 旨在成为一个主要的患者评估，研究和教育 中西部上游的资源。 流行病学研究使用 马约诊所的人口数据库提供了第一个年龄-和 美国痴呆症的性别特异性发病率。 马约诊所ADRC将通过一项 进行前瞻性社区调查，以确定城市地区的流行率 和明尼苏达州奥姆斯特德县的农村人口。 病例/对照研究 旨在评估病因风险因素，包括家族性 聚集、环境和职业毒性暴露。 在 在社区调查过程中，有大量的非痴呆老年人 将确定受试者，并为常用的标准值 对老年人和非常老年人（80岁和 将成立。 这种自抗扰控制器的一个独特之处是它的能力 比较社区人口和转诊人口， 人口统计学和临床特征以及 生存。 一个神经药理学研究项目将研究毒蕈碱乙酰胆碱 阿尔茨海默病中的受体亚型。 一个神经成像项目将 将内侧颞叶结构的体积变化与 通过磁共振成像测量和测量的功能变化 通过神经心理学的单光子发射计算机断层扫描， 阿尔茨海默病患者的临床和人口统计学特征 和正常对照组之间进行纵向比较。 拟议的ADRC在最初几年的主要重点是 为阿尔茨海默病患者建立一个区域转诊中心 疾病 马约诊所正在扩大其承诺， 通过建立阿尔茨海默病研究设施来进行疾病研究 作为其佛罗里达杰克逊维尔诊所的一部分。 预计该 拟议的ADRC将扩大到包括杰克逊维尔的活动， 未来几年。