Defining the role of Microphthalmia-associated Transcription Factor (MITF) in melanoma heterogeneity by real-time cell cycle imaging

通过实时细胞周期成像定义小眼相关转录因子（MITF）在黑色素瘤异质性中的作用

• 批准号: nhmrc : GNT1084893
• 负责人: A/Pr Helmut Schaider
• 金额: $ 59.45万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-microphthalmia-cycle-imaging/1345587
• 关键词: Defining; role; Microphthalmia; associated; Transcription

Metastatic melanoma is highly therapy-resistant. Modern targeted therapy is promising but suffers from rapid onset of drug resistance. Tumours consist of zones of fast growing cells next to zones of dormant cells. This tumour heterogeneity is one of the reasons for cancer drug resistance, as cells in different growth states respond differently to drugs. By understanding the causes of tumour heterogeneity we will set the basis for innovative clinical approaches against this devastating disease.

转移性黑色素瘤是高度耐药的。现代靶向治疗前景看好，但存在快速产生耐药性的问题。肿瘤由快速生长的细胞区和休眠细胞区组成。这种肿瘤的异质性是癌症耐药性的原因之一，因为处于不同生长状态的细胞对药物的反应不同。通过了解肿瘤异质性的原因，我们将为针对这种毁灭性疾病的创新临床方法奠定基础。