PILOT STUDY--HORMONAL REGULATION OF EXTRACELLULAR FLUID VOLUME IN THE OLD

试点研究--老年人细胞外液量的激素调节

• 批准号: 3809499
• 负责人: BARBARA A CLARK
• 金额: --
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3809499
• 关键词: aging; atrial natriuretic peptide; body water; homeostasis; hormone regulation /control mechanism; human middle age (35-64); human old age (65+); hyponatremia; radioimmunoassay; renin angiotensin system; saluresis; vascular resistance; vasopressins; young adult human (21-34)

Dr. Barbara Clark was selected for career initiation support by the Research Development Core Advisory Committee for her proposal "Hormonal Regulation of Extracellular Fluid Volume in the Old." Dr. Clark is a trainee in the Physician Scientist Training Program entering Phase II, or the early stage of independent investigation and has developed a parallel set of investigations to her primary interest in the physiology of renal sodium excretion. Support for the proposed two years of pharmacologic study of ANP in the elderly will broaden Dr. Clark's systematic examination of renal physiology and aging. Dr. Clark will continue to work with her mentor, Dr. Franklin Epstein, Chief of Nephrology at the Beth Israel Hospital, examining the hypothesis that 1) aging is associated with altered release of ANP in response to volume stimuli, 2) age-related elevation of ANP levels seen in aging are associated with end organ renal and vascular resistance, 3) elevated ANP levels seen with age may be responsible for lower basal vasopressin levels and 4) aging is associated with increased susceptibility for hyponatremia. The proposed studies, conducted largely in the Beth Israel Hospital Clinical Research Center will be supervised by Dr. Franklin Epstein, an internationally respected Academic Nephrologist and Professor of Medicine at Harvard Medical School. The RIA, Subject Recruitment, and the Physiology Cores will be necessary components of Dr. Clark's research support.

芭芭拉·克拉克（Barbara Clark）博士被选中 研究开发核心咨询委员会的提议 “旧细胞外流体体积的荷尔蒙调节。” 克拉克博士是医师科学家培训计划的实习生 进入II期或独立研究的早期阶段 并已向她的小学开发了一套平行的调查 对肾脏钠排泄生理学的兴趣。 支持 ANP在老年人中提出的两年的药理学研究 将扩大克拉克博士对肾脏生理的系统检查 和老化。 克拉克博士将继续与她的导师富兰克林博士一起工作 爱泼斯坦（Epstein），贝丝以色列医院的肾脏科负责人 1）衰老与释放改变有关的假设 ANP响应体积刺激，2）与年龄相关的ANP升高 衰老中看到的水平与最终器官肾脏有关 血管抗性，3）随着年龄的增长，ANP水平升高可能是 负责较低的基底加压素水平，4）衰老是 与低钠血症的易感性增加有关。 这 拟议的研究主要在贝丝以色列医院进行 临床研究中心将由富兰克林博士监督 爱泼斯坦，国际尊敬的学术肾脏科医生和 哈佛医学院医学教授。 RIA，主题 招聘和生理核心将是必要的组成部分 克拉克博士的研究支持。