PILOT STUDY--HORMONAL REGULATION OF EXTRACELLULAR FLUID VOLUME IN THE OLD

试点研究--老年人细胞外液量的激素调节

• 批准号: 3809499
• 负责人: BARBARA A CLARK
• 金额: --
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3809499
• 关键词: aging; atrial natriuretic peptide; body water; homeostasis; hormone regulation /control mechanism; human middle age (35-64); human old age (65+); hyponatremia; radioimmunoassay; renin angiotensin system; saluresis; vascular resistance; vasopressins; young adult human (21-34)

Dr. Barbara Clark was selected for career initiation support by the Research Development Core Advisory Committee for her proposal "Hormonal Regulation of Extracellular Fluid Volume in the Old." Dr. Clark is a trainee in the Physician Scientist Training Program entering Phase II, or the early stage of independent investigation and has developed a parallel set of investigations to her primary interest in the physiology of renal sodium excretion. Support for the proposed two years of pharmacologic study of ANP in the elderly will broaden Dr. Clark's systematic examination of renal physiology and aging. Dr. Clark will continue to work with her mentor, Dr. Franklin Epstein, Chief of Nephrology at the Beth Israel Hospital, examining the hypothesis that 1) aging is associated with altered release of ANP in response to volume stimuli, 2) age-related elevation of ANP levels seen in aging are associated with end organ renal and vascular resistance, 3) elevated ANP levels seen with age may be responsible for lower basal vasopressin levels and 4) aging is associated with increased susceptibility for hyponatremia. The proposed studies, conducted largely in the Beth Israel Hospital Clinical Research Center will be supervised by Dr. Franklin Epstein, an internationally respected Academic Nephrologist and Professor of Medicine at Harvard Medical School. The RIA, Subject Recruitment, and the Physiology Cores will be necessary components of Dr. Clark's research support.

芭芭拉·克拉克博士被选为职业生涯启动支持由 研究及发展核心咨询委员会 “老年人细胞外液量的激素调节。" 博士克拉克是一名实习医生科学家培训计划 进入第二阶段，即独立调查的早期阶段 并开发了一套与她的主要研究平行的研究， 对肾脏钠排泄的生理学感兴趣。 支持 建议在老年人中进行为期两年的ANP药理学研究 将扩展克拉克医生对肾脏生理学的系统检查 和衰老。 博士克拉克将继续与她的导师富兰克林博士一起工作 爱泼斯坦是贝斯以色列医院的肾脏科主任， 假设1）衰老与改变释放的 心钠素对容积刺激的反应，2）年龄相关的心钠素升高 在衰老中观察到的水平与终末器官肾和 血管阻力，3）随着年龄的增长， 负责较低的基础血管加压素水平和4）老化是 与低钠血症易感性增加有关。 的 主要在贝斯以色列医院进行的拟议研究 临床研究中心将由富兰克林博士监督 爱泼斯坦是一位国际知名的学术肾病学家， 哈佛医学院的医学教授。 RIA，主题 招募和生理学核心将是必要的组成部分 克拉克博士的研究经费