更昔洛韦 ( /-) RGM-GSF 治疗艾滋病相关巨细胞病毒视网膜炎的 III 期研究-猫眼课题宝

更昔洛韦 ( /-) RGM-GSF 治疗艾滋病相关巨细胞病毒视网膜炎的 III 期研究

批准号：

3884901

负责人：

DOUGLAS DIETERICH

金额：

$0.0万

依托单位：

NEW YORK UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3884901

关键词：

AIDS Betaherpesvirinae T lymphocyte antiAIDS agent clinical trials drug adverse effect gene expression human immunodeficiency virus human subject human therapy evaluation immunopathology chemotherapy leukopenia retinitis virus genetics

中文摘要

翻译

这项研究将确定以前对更昔洛韦不耐受的患者

英文摘要

This study will determine in patients previously intolerant to ganciclovir because of neutropenia whether co-administration of GM-CSF improves tolerance and if this improvement is associated with a favorable clinical outcome, as defined by a delayed time-to-progression of retinitis. It will also assess change in the expression of HIV p 24 antigen in the serum and number of T4+ lymphocytes in the blood, and it will confirm the safety of co-administration of ganciclovir and GM-CSF>

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