ASSESSMENT OF MICROVASCULAR ENDOTHELIUM--DEPENDENT REACTIVITY

微血管内皮的评估——依赖性反应性

• 批准号: 3899240
• 负责人: J A PANZA
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3899240
• 关键词: acetylcholine; atherosclerosis; cardiovascular pharmacology; disease /disorder model; human subject; hypertension; muscle relaxation; nitroferricyanide; phentolamine; vascular endothelium; vascular smooth muscle; vasoactive agent; vasomotion

Previous studies have shown that the endothelium regulates vascular tone by modulating the activity of vascular smooth muscle. It has also been demonstrated that the endothelium plays an important role in atherosclerosis and animal models of hypertension. The present study was designed to determine whether patients with essential hypertension have an endothelium-dependent abnormality in vascular relaxation. For this purpose, we have utilized intra- arterial infusion of acetylcholine (an endothelium-dependent vasodilator) and sodium nitroprusside (a direct smooth muscle dilator) in hypertensive patients and in a control group of normal volunteers. The results of this study suggest that patients with essential hypertension have an impairment in endothelial-mediated vascular relaxation that may either cause or exacerbate the hypertensive process.

以前的研究表明，内皮细胞调节血管 通过调节血管平滑肌的活动来调节张力。 它有 内皮细胞也被证明在 在动脉粥样硬化和高血压动物模型中。 本研究旨在确定是否有 原发性高血压具有内皮依赖性异常 血管松弛 为此，我们使用了内- 动脉灌注乙酰胆碱（内皮依赖性 血管扩张剂）和硝普钠（直接平滑肌 扩张器）在高血压患者和正常对照组 志愿者 这项研究的结果表明，患有必要疾病的患者 高血压患者内皮介导血管 可能导致或加剧高血压的放松 过程