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PROTEIN TRANSLATION INITIATION FACTOR 4D--STRUCTURE, BIOSYNTHESIS AND CONTROL

PROTEIN TRANSLATION INITIATION FACTOR 4D--STRUCTURE, BIOSYNTHESIS AND CONTROL
蛋白质翻译起始因子 4D——结构、生物合成和控制
批准号：
3896749
负责人：
M H PARK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3896749
关键词：
butyrates chemical structure function eukaryote genetic translation hormone regulation /control mechanism hydroxylation lysine polyamines protein biosynthesis protein structure function puromycin spermidine

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中文摘要
翻译
真核蛋白翻译起始因子4D （eIF-4D）含有一个
英文摘要
Eukaryotic protein translation initiation factor 4D (eIF-4D) contains one residue of hypusine and appears to be the only cellular protein with this one unique amino acid. Hypusine is produced posttranslationally by transfer of the butylamine portion of the polyamine spermidine to a lysine residue in the eIF-4D precursor and subsequent hydroxylation. These findings reveal a novel cellular metabolic pathway. Comparison of activity of mature eIF-4D and eIF-4D precursors that contain unmodified lysine in place of hypusine in methionyl-puromycin synthesis indicate that hypusine is essential for the activity of eIF-4D in this model protein synthesis initiation system. Studies are underway to relate the structure of hypusine to the physiological function of eIF-4D and to its mode of action in eukaryotic protein synthesis.
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ESSENTIAL CELLULAR FUNCTION OF HYPUSINE IN ELF 5A
PROTEIN TRANSLATION INITIATION FACTOR 4D--STRUCTURE, BIOSYNTHESIS AND CONTROL
HYPUSINE IN EIF-4D--BIOSYNTHESIS AND FUNCTION
ESSENTIAL CELLULAR FUNCTION OF HYPUSINE IN ELF 5A
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