Delivering on the GWAS promise: from genetic discoveries to novel drug targets for asthma

本研究的目的是确定哮喘的新药物靶点。这一点很重要，因为对于10名哮喘患者中的6名，目前的治疗不能充分控制疾病症状，因此这些患者发生严重急性发作的风险较高。我认为，识别哮喘风险基因是我们识别哮喘新药靶点的最佳机会。在这项研究中，我将确定新的哮喘风险基因，并测试阻断这些基因是否可以减轻疾病症状。

The aim of this study is to identify new drug targets for asthma. This is important because for 6 in 10 asthma patients, current treatments do not adequately control disease symptoms and so these individuals are at a higher risk of having severe exacerbations. I propose that identifying asthma risk genes represents our best chance to identify novel drug targets for asthma. In this study, I will identify new asthma risk genes and test whether blocking these genes can alleviate disease symptoms.