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CHARACTERIZATION OF T CELL RECEPTOR GENES IN ALLOREACTIVE CLONES

CHARACTERIZATION OF T CELL RECEPTOR GENES IN ALLOREACTIVE CLONES
同种反应性克隆中 T 细胞受体基因的特征
批准号:
3939366
负责人:
H GOLDING
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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中文摘要
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英文摘要
A panel of alloreactive T cell clones derived from a single donor has been established and characterized for its fine specificity patterns. It has thus been possible to assign each of the clones to one of four fine specificity groups. In order to attempt to correlate fine specificity with receptor gene utilization, the TcR alpha and beta variable gene segments used by these clones are being analyzed. An alpha variable gene derived from a member of the most common group is being isolated from a restricted cDNA library. Its representation in the other members of the panel will be assessed.
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