2'DCF IN IFN-RESISTANT HAIRY CELL LEUKEMIA OR T GAMMA LYMPHOPROLIF. DISORDER

2DCF 治疗干扰素抵抗性毛细胞白血病或 T GAMMA LYMPHOPROLIF。

• 批准号: 3939595
• 负责人: R G STEIS
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939595
• 关键词: antineoplastic antibiotics; drug adverse effect; hairy cell leukemia; human subject; human therapy evaluation; interferons; lymphatic disorder; lymphoma; metastasis; neoplasm /cancer chemotherapy

The BRMP has an ongoing study of recombinant alpha interferon in patients with hairy cell leukemia. A number of these patients have developed disease progression despite continued administration of interferon. Administration of higher doses of interferon has resulted in only minor and transient further tumor responses. This trial was designed as a salvage trial for these patients. Three patients have been admitted to this trial so far and 2 of these have achieved a partial response. All 3 patients had significant cytopenias when they started the study and all were refractory to interferon. The 2 partial responses occurred very rapidly after administration of deoxycoformycin but were associated with transient episodes of severe thrombocytopenia and febril neutropenia. One patient died after 2 doses of deoxycoformycin due to refractory and transfusion-resistant thrombocytopenia. These partial responses have been substantial with only minimal, scant hairy cells identifiable in bilateral iliac crest bone marrow biopsies. One patient with the T-gamma lymphoproliferative disorder has so far been treated on this study. This patient has not responded to date. Toxicity associated with administration of dCF has included significant myelosuppression, fatigue, nausea, and vomiting.

BRMP正在进行重组α干扰素的研究 在毛细胞白血病患者中。这些患者中有一些 已经发展出疾病的进展，尽管继续 给药干扰素。给药剂量较大的 干扰素只导致了轻微和短暂的进一步肿瘤。 回应。这项试验被设计为对这些 病人。 到目前为止，已有3名患者入院参加这项试验，其中2名 这些都取得了部分回应。所有3名患者都有 当他们开始研究时，所有人都出现了显著的细胞减少症 对干扰素无效。这两个部分反应非常明显。 在服用脱氧考福霉素后很快，但 与一过性严重的血小板减少症有关 和发烧的中性粒细胞减少症。一名患者在服用两剂后死亡 脱氧考福霉素致耐药输液耐药 血小板减少症。这些部分反应是相当可观的 双侧髂骨仅可见极少的毛细胞 冠状骨髓活检。 一名患有T-γ淋巴增生性疾病的患者 到目前为止都是在这项研究上治疗的。这位病人没有反应。 到目前为止。 与服用DCF相关的毒性包括 严重的骨髓抑制、疲劳、恶心和呕吐。