Dendritic cells in Graft-versus-Host Disease following Bone Marrow Transplantation

骨髓移植后移植物抗宿主病中的树突状细胞

• 批准号: nhmrc : 1016341
• 负责人: Dr Kate Markey
• 金额: $ 12.06万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dendritic-cells-graft-marrow-transplantation/109766
• 关键词: Dendritic; cells; Graft; versus; Host

Bone marrow transplantation (BMT) is the only available curative therapy for many blood cancers such as leukaemia. Graft-versus-host disease (GVHD) occurs after BMT and is a major cause of transplant-related death. GVHD occurs when transplanted donor cells “attack” recipient tissues causing widespread damage. Gaining a more comprehensive understanding of this disease process is critically important for the design of new therapies and improvement of outcomes for transplant recipients.

骨髓移植（BMT）是治疗白血病等多种血癌的唯一有效疗法。移植物抗宿主病（GVHD）发生在骨髓移植后，是移植相关死亡的主要原因。当移植的供体细胞“攻击”受体组织时，发生GVHD，造成广泛的损伤。更全面地了解这一疾病过程对于设计新的治疗方法和改善移植受者的结局至关重要。