皮质和纹状体多巴胺能活动之间的神经化学相互作用-猫眼课题宝

皮质和纹状体多巴胺能活动之间的神经化学相互作用

批准号：

3921913

负责人：

M P HEYES

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF MENTAL HEALTH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3921913

关键词：

6 hydroxydopamine Primates cerebellar cortex cognition disorders corpus striatum dopamine dopamine receptor drug administration routes frontal lobe /cortex laboratory rat mental disorder diagnosis motivation neurochemistry neurophysiology nucleus accumbens problem solving putamen schizophrenia sympathetic nervous system

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英文摘要

Disturbances in the balance of regional brain dopaminergic activity have been implicated in the symptomatology of schizophrenia. Recent studies in patients have led to the hypothesis that dysfunction in the dorsolateral prefrontal cortex (DLPFC) may cause the impaired motivation, shallow affect, and deficiencies in the performance of problem solving tasks suffered by schizophrenics. Analogous deficits are produced in primates by depletion of dopamine from the DLPFC. Together these observations suggest a role for DLPFC dopaminergic neurons in cognitive functions subserved by this area. Studies in rats have indicated that dopaminergic activity in the medial frontal cortex exerts a suppressive effect of dopaminergic activity in the striatum and nucleus accumbens. Weinberger has postulated that decreased dopaminergic activity in the DLPFC in schizophrenia may increase dopaminergic activity in striatum resulting in the positive features of schizophrenia. To determine whether a reciprocal relationship between prefrontal and sub-cortical dopaminergic activity exists in primates, dopamine was depleted in juvenile rhesus monkeys by local injections of 6-hydroxydopamine. Neurochemical analysis indicated that dopaminergic activity was increased in the putamen.

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