PURCHASE OF AN AMINO ACID ANALYZER AND SEQUENCER

购买氨基酸分析仪和测序仪

• 批准号: 3519892
• 负责人: JAMES M SODETZ
• 金额: $ 17万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-11 至 1989-04-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519892
• 关键词: aminoacid analyzer; biomedical equipment purchase; ion exchange chromatography; protein sequence

The University of South Carolina will purchase a sensitive, high performance amino acid analyzer and amino acid sequencer with support from the Biomedical Research Support Shared Instrumentation Program. These instruments will form the basis for a core facility that will provide services to researchers on campus. Seven investigators in the Department of Chemistry and Biology will be major users of this equipment in studies of: (a) the mechanism of diabetes-related protein crosslinking by glucose and effects of free radical reactions on protein structure and aging; (b) the active site environment of thymidylate synthase, and enzyme target for chemotherapeutic agents used in cancer treatment; (c) proteins involved in nuclear DNA condensation during spermatogenesis and in sperm motility; (d) the role of selenium in biomolecules; (e) the molecular basis for interactions between human complement proteins that result in target cell death; (f) the role of alkaline phosphatase and its inducer in mineralization reactions in cartilage; (g) proteins involved in electron transport in photosynthetic bacteria. In addition, twelve auxiliary users will require these instruments in a variety of research projects. The requested equipment will represent a major improvement in biochemical research instrumentation at this University and significantly enhance its ability to support existing and planned research programs.

南卡罗来纳州大学将购买一个敏感的，高 高性能氨基酸分析仪和氨基酸测序仪， 生物医学研究支持共享 仪表计划。 这些文书将构成基础 为研究人员提供服务的核心设施， 校园 化学系的七名研究人员和 生物学将是这一设备的主要用户，用于以下研究： 糖尿病相关蛋白质通过葡萄糖交联的机制， 自由基反应对蛋白质结构和衰老的影响; (b)胸苷酸合成酶活性位点环境，和 用于癌症的化学治疗剂的酶靶 处理;（c）参与核DNA凝聚的蛋白质 在精子发生过程中和精子运动中;（d） 生物分子中的硒;（e）相互作用的分子基础 在人类补体蛋白中， 死亡;（f）碱性磷酸酶及其诱导剂在 软骨中的矿化反应;（g）参与 光合细菌的电子传递 此外，十二 辅助用户将需要这些仪器在各种 研究项目。 所要求的设备将是一项重大改进， 生化研究仪器， 大大提高其支持现有和计划中 研究项目。