DISCOVERY OF GENES THAT PROTECT AGAINST TAU-INDUCED NEUROPATHOLOGY

痴呆症造成了50亿美元的直接医疗成本，影响了30万澳大利亚人，而且发病率还在增加。迫切需要新的治疗方法。痴呆症与大脑中的tau蛋白聚集体有关。找到预防tau聚合体引起的症状的基因将有助于开发新的治疗方法，但识别此类基因一直非常困难和昂贵。我们将利用我们世界领先的资源来革命性地发现基因，并确定可以预防痴呆症的基因。

Dementia incurs $5 billion of direct health costs, affects 300,000 Australians and its incidence is increasing. New treatments are urgently needed. Dementia is associated with tau protein aggregates in the brain. Finding genes that prevent symptoms caused by tau aggregates will help develop new treatments, but identifying such genes has been very difficult and expensive. We will use our world-leading resource to revolutionize gene discovery and identify genes that can protect against dementia.