STUDIES OF THE NATURAL HISTORY AND TREATMENT OF DUCK HEPATITIS B VIRUS INFECTION

它们在结构和性质上有许多相似之处， 人B型肝炎病毒和鸭B型肝炎病毒（DHBV）。 这使得鸭乙型肝炎病毒感染鸭是一个非常有用的实验 人HBV感染模型，特别是HBV不能被 在细胞培养中容易生长。 出生时感染鸭乙型肝炎病毒的鸭 成为病毒的慢性携带者，尽管他们可能不会 发展为显性肝炎。 一些DHBV感染的鸭子 据报道，发展肝细胞癌，肿瘤强烈 在人类中与慢性B型肝炎感染的病因学相关。 正在评估新的抗病毒免疫调节剂， 它们抑制鸭乙型肝炎病毒复制的能力作为筛选 慢性B型肝炎新有效疗法的试验 伙计

There are many similarities in structure and properties between the human hepatitis B virus and duck hepatitis B virus (DHBV). This makes DHBV infection in ducks a very useful experimental model of human HBV infection, particularly as HBV cannot be grown readily in cell culture. Ducks infected with DHBV at birth become chronic carriers of the virus, although they may not develop overt hepatitis. Some DHBV-infected ducks have been reported to develop hepatocellular carcinoma, a tumor strongly linked etiologically in humans with chronic hepatitis B infection. New antiviral immunomodulatory agents are being assessed for their ability to suppress DHBV replication in ducks as a screening test for new effective therapies for chronic type B hepatitis in man.