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STUDIES ON THE ACTIVE SITES OF CYTOCHROMES P-450

STUDIES ON THE ACTIVE SITES OF CYTOCHROMES P-450
细胞色素 P-450 活性位点的研究
批准号：
3942797
负责人：
K KORZEKWA
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3942797
关键词：
chemical reaction cytochrome P450 enzyme structure enzyme substrate hydroxylation isozymes stereochemistry steroid analog steroid metabolism

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英文摘要
Cytochrome P-450a is a P-450 isozyme showing a high degree of regiospecificity of the 7 alpha-hydroxylation of steroids. The steric and electronic binding properties responsible for this specificity will be probed by evaluating the metabolism of several steroid analogs or fragments. Models used in this study include aliphatic and unsaturated ring systems steroid fragments, and a potential heme-binding optically active steroid analog. The regioselectivity, chiral and prochiral selectivity, and kinetics of the metabolism of these substrates will be used to evaluate the geometric properties of the P-450a active site.
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STUDIES ON THE ACTIVE SITES AND MECHANISMS OF CYTOCHROME P450
STUDIES ON THE CONVERSION OF ANDROGENS TO ESTROGENS BY AROMATASE
THEORETICAL MODELS FOR CYTOCHROME P-450 MEDIATED HYDROGEN ATOM ABSTRACTION
STUDIES ON THE ACTIVE SITES OF CYTOCHROMES P-450
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