EFFECT OF SODIUM INTAKE ON RENAL DOPA METABOLISM

在之前的一项研究中，蛋白质喂养通常会增加 在不改变血浆DOPA的情况下，尿多巴胺被证明是 当DOPA脱羧酶被抑制时，血浆DOPA升高。 这些观察得出的结论是，蛋白质喂养 增加了DOPA向肾脏的输送，从而增加了 肾脏多巴胺的形成。因为钠摄入量的增加 也会刺激肾脏多巴胺的形成，有可能 它通过对DOPA代谢的变化进行了研究。 当钠摄入量从109mEq/天减少到9mEq/天时 正常受试者持续的新陈代谢饮食，肾脏清除和 多巴酚A排泄量减少。当钠摄入量增加时 从9mEq/d到249mEq/d，肾清除和多巴排泄 分别增加82%和62%；排泄物 多巴胺增加了23%。肾小球滤过率的变化 多巴的出现与血浆多巴无明显变化。结果是 与钠离子变化的解释一致 摄入量可能通过改变DOPA而影响肾脏多巴胺的形成 新陈代谢，进而将其输送到肾脏。

In a previous study, protein feeding, which normally increases urinary dopamine without a change in plasma DOPA, was shown to increase plasma DOPA when DOPA decarboxylase was inhibited. These observations led to the conclusion that protein feeding increased the delivery of DOPA to the kidney, thereby increasing renal formation of dopamine. Since an increase in sodium intake also stimulates renal formation of dopamine, the possibility that it does so through changes in DOPA metabolism was studied. When sodium intake was decreased from 109 to 9 mEq/day in normal subjects on a constant metabolic diet, renal clearance and excretion of DOPA decreased. When sodium intake was increased from 9 to 249 mEq/d, renal clearance and excretion of DOPA increased by 82% and 62% respectively; the excretion of dopamine increased by 23%. The changes in renal clearance of DOPA occurred without a change in plasma DOPA. The results are consistent with the interpretation that changes in sodium intake may affect renal dopamine formation by altering DOPA metabolism and, in turn, its delivery to the kidney.