UNIV OF PA CLINICAL SMELL & TASTE RESEARCH CENTER

本申请是对大学继续支持的请求。 宾夕法尼亚州临床味觉和味觉研究中心，第一个临床 美国的一个研究中心，专门研究 化学感官 该中心提供资源和科学重点， 跨学科的临床和基础研究， 了解、诊断、治疗和管理 嗅觉和味觉功能障碍 数据来源：National Ambulatory 医疗保健调查显示，1975年和1976年的总和为435，000人， 访问医生的办公室发生在其中一个主要的介绍 抱怨是化学感觉的性质，我们的中心是少数几个 致力于了解和治疗患有 这些问题 主要行政办公室和诊断 该中心的设施位于大学医院内 宾夕法尼亚州。 中心实验室位于学校内， 医学，牙科医学和兽医学，以及在 费城退伍军人管理医疗中心。 新的核心 中心的设施，其中中心的受控环境室 和人体空气稀释嗅觉仪的位置，作为主要的 该中心的人类研究的位置，并直接定位 毗邻临床设施的部门 耳鼻咽喉科学与人类交流系 神经外科学、牙科医学系、语言和听力 中心 这一优越的地理位置促进了我们的中心之间的直接互动 以及医院内的这些和其他部门。 该中心目前 建立了一个基于计算机的患者登记研究在我们的设施 （根据临床记录、标准化摄入访谈和医疗记录） 和感官评价），为研究 化学感觉障碍的病因学，它们的自然史，临床 表现和对治疗的反应。 在接下来的五年里，我们 我们计划继续研究三个主要项目（发展 诊断测试;嗅觉电生理学;糖尿病中的葡萄糖接收）， 以及在（a）生物化学和 （B）味觉、唾液和分泌过程的生物物理学， 口腔干燥症的病理生理学，和（c）神经内分泌调节 嗅觉灵敏度

This application is a request for continued support of the University of Pennsylvania Clinical Smell and Taste Research Center, the first Clinical Research Center in the United States devoted solely to the study of the chemical senses. This Center provides the resources and scientific focus for interdisciplinary clinical and fundamental research related to the understanding, diagnosis, treatment and management of patients with olfactory and gustatory dysfunctions. Data from the National Ambulatory Medical Care Survey suggest that, for 1975 and 1976 combined, 435,000 visits to physicians' offices occurred in which a major presenting complaint was chemosensory in nature, and our Center is one of the few national institutions devoted to understanding and treating patients with these problems. The primary administrative offices and diagnostic facilities of the center are located within the Hospital of the University of Pennsylvania. Center laboratories are located within the Schools of Medicine, Dental Medicine, and Veterinary Medicine, as well as in the Veterans Administration Medical Center of Philadelphia. The new Core Facility of the Center, in which the Center's controlled environment room and human air-dilution olfactometer are located, serves as the primary location for the Center's human studies, and is positioned directly adjacent to the clinical facilities of the Department of Otorhinolaryngology and Human Communication, the Department of Neurosurgery, the Department of Dental Medicine, and the Speech and Hearing Center. This prime location fosters direct interactions between our Center and these and other departments within the Hospital. The Center has now established a computer-based registry of patients studied in our facility (based upon clinical records, standardized intake interviews, and medical and sensory evaluations), providing a rich data base for the study of the etiology of chemosensory disorders, their natural history, clinical manifestations, and response to therapy. During the next five years, we plan to continue studies in our three major project areas (development of diagnostic tests; olfactory electrophysiology; glucoreception in diabetes), as well as to develop new projects in the areas of (a) the biochemistry and biophysics of taste, saliva, and secretory processes, (b) the pathophysiology of Xerostomia, and (c) the neuroendocrine modulation of olfactory sensitivity.