DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR).

尽管进行了手术，食管癌的生存率仍然很低。对术前化疗有反应的患者比那些没有反应的患者生存率更高。本研究建议使用早期FDG-PET扫描来识别对标准化疗无反应的患者。这将允许及时改变治疗方案，使用新的药物进行放疗或不进行放疗，旨在改善预后。这代表了食管癌治疗模式的转变。

Oesophageal cancer continues to have poor survival despite surgery. Patients responding to pre-operative chemotherapy have better survival than those who do not. This study proposes using early FDG-PET scan to identify patients not responding to standard chemotherapy. This will permit the timely change of therapy to alternative regimens with a newer agent with or without radiotherapy, aiming to improve outcomes. This represents a paradigm shift in the management of oesophageal cancer.