DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR).

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Oesophageal cancer continues to have poor survival despite surgery. Patients responding to pre-operative chemotherapy have better survival than those who do not. This study proposes using early FDG-PET scan to identify patients not responding to standard chemotherapy. This will permit the timely change of therapy to alternative regimens with a newer agent with or without radiotherapy, aiming to improve outcomes. This represents a paradigm shift in the management of oesophageal cancer.