The role of Fc gamma receptors in regulating the response to antibody therapy

许多治疗性抗体通过与免疫效应细胞上发现的Fc伽马受体结合来发挥作用。目前尚不清楚效应器细胞是否有助于杀死目标细胞，或者它们是否只是提供了一种手段，使抗体分子交联，从而向抗体分子传递致命信号。该项目旨在确定其中哪一个更重要，并破译哪些免疫细胞参与其中。如果我们了解这一过程，我们就可以寻求改进目前的抗体疗法，使其更有效或毒性更低

Many therapeutic antibodies work by binding to Fc gamma Receptors- found on immune effector cells. It is not clear whether the effector cells are instrumental in killing the target cells, or whether they simply provide a means to cross-link the antibody molecules, and thereby deliver lethal signals into them. This project aims to determine which of these is more important, and to decipher which immune cells are involved. If we understand this process we can seek to improve current antibody therapies to make them more efficacious or less toxic