The role of Fc gamma receptors in regulating the response to antibody therapy

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Many therapeutic antibodies work by binding to Fc gamma Receptors- found on immune effector cells. It is not clear whether the effector cells are instrumental in killing the target cells, or whether they simply provide a means to cross-link the antibody molecules, and thereby deliver lethal signals into them. This project aims to determine which of these is more important, and to decipher which immune cells are involved. If we understand this process we can seek to improve current antibody therapies to make them more efficacious or less toxic