Wessex severe asthma cohort

威塞克斯严重哮喘队列

• 批准号: G0800649/1
• 负责人: Peter Howarth
• 金额: $ 84.95万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800649%2F1
• 关键词: Wessex; severe; asthma; cohort

Asthma is a common and disabling problem for many, particularly those with severe persistent disease that prevents them living a normal life. Standard asthma therapies are insufficient to control symptoms in these individuals and they live in fear of exacerbations that require emergency care and hospitalisation. There is thus an urgent need for the identification of novel therapeutic approaches that improve disease control and prevent disease exacerbation. To enable the more rapid conduct of trials with potential new treatments it is important to have well characterised patients, as it is recognised that severe asthma may arise from a range of causes and not all individuals are likely to benefit in the same way with specific interventions. With this in mind, this proposal will gather patients within the Wessex region with severe asthma, to form a Wessex severe asthma cohort, that can undergo detailed characterisation and be available to potentially take parts in trials of new therapies. This characterisation will involve documenting the impact of the disease on daily symptoms and quality of life, focusing on the presence and severity of nasal and sinus symptoms. Measures will be made of how well the lungs are working through a series of breathing tests. Biological samples, such as sputum, collected by inducing coughing, nasal washings, blood and urine will be collected and used to assess the nature, extent and severity of asthmatic inflammation within the airways and body. It is intended that the cohort would act as a focus for the evaluation of novel treatments that are being developed in the hope that they would lead to improvement in asthma in those with more severe disease. The characterisation would help determine which patients might best be selected for different interventions, dependent upon how these work, to give the best chance of identifying better treatments that can be developed to help improve the quality of life in those with severe asthma.

哮喘对许多人来说是一种常见的致残性问题，特别是那些患有严重持续性疾病的人，这些疾病使他们无法过正常的生活。标准的哮喘治疗不足以控制这些人的症状，他们生活在需要紧急护理和住院治疗的病情加重的恐惧中。因此，迫切需要鉴定改善疾病控制和预防疾病恶化的新型治疗方法。为了能够更快地进行潜在新疗法的试验，重要的是要有良好的患者特征，因为人们认识到严重哮喘可能由一系列原因引起，并且并非所有个体都可能以相同的方式受益于特定的干预措施。考虑到这一点，该提案将收集威塞克斯地区的重度哮喘患者，以形成一个威塞克斯重度哮喘队列，该队列可以进行详细的表征，并可用于潜在的新疗法试验。这种表征将涉及记录疾病对日常症状和生活质量的影响，重点是鼻和鼻窦症状的存在和严重程度。将通过一系列呼吸测试来衡量肺的工作情况。将采集通过诱导咳嗽、鼻腔冲洗、血液和尿液采集的生物样本（如痰液），并用于评估气道和体内哮喘炎症的性质、程度和严重程度。该队列将作为正在开发的新治疗方法的评价重点，希望它们能够改善患有更严重疾病的哮喘患者的病情。这种表征将有助于确定哪些患者最适合进行不同的干预，这取决于这些干预的工作方式，以便最好地确定可以开发的更好的治疗方法，以帮助改善重度哮喘患者的生活质量。