The ConDuCT Hub: Collaboration and Innovation for Difficult or Complex Randomised Controlled Trials

ConDuCT 中心：困难或复杂的随机对照试验的协作和创新

• 批准号: G0800800/1
• 负责人: Jane Blazeby
• 金额: $ 232.16万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800800%2F1
• 关键词: ConDuCT; Hub; Collaboration; Innovation; Difficult

The overall aim of the MRC ConDuCT Hub is to provide the conditions for research staff to come together and develop new techniques to design and complete randomised controlled trials (RCTs). RCTs are the most powerful form of medical research that can change what doctors advise. RCTs can compare outcomes for patients receiving different treatments or compare new treatments with existing treatments, or a placebo (dummy treatment). Researchers assign participants to each treatment group at random to ensure that comparison between the two groups is scientifically accurate as all other things apart from the treatment are likely to be comparable in each group. Although RCTs provide good evidence, many are very difficult to design and complete, e.g. some are not completed because they are unable to recruit enough patients. Other RCTs are not started because the issues require complex design, conduct and analysis of results. The MRC ConDuCT Hub will concentrate on research that allows RCTs considered clinically important but too ?difficult?, to be undertaken successfully. The Hub should thus eventually lead to changes in clinical practice and better information for doctors and patients about which treatments to choose, based on the best evidence. This will be achieved by bringing together an experienced team with different research backgrounds to develop new ways of carrying out RCTs. The Hub will be directed by a surgeon who works in the NHS and already carries out research to improve RCTs. Researchers in the Hub will work with other MRC Hubs across the UK and with NHS organisations in South West England and South Wales to carry out this work. The ConDuCT Hub will provide a training programme of short courses and workshops based on each of six research themes. This will provide basic and advanced learning opportunities for researchers and clinicians designing and conducting RCTs. New courses and PhD studentships will be provided in the specialist research areas. In conclusion, the ConDuCT Hub will bring together researchers and clinicians to improve the design of RCTs. This will lead to more and better RCTs being started and completed. The ConDuCT Hub will focus on tackling important questions about the best treatments and should lead to better information for patients and doctors making decisions about which treatments to use.

MRC行为中心的总体目标是为研究人员提供条件，使他们能够聚集在一起，开发设计和完成随机对照试验（RCTs）的新技术。随机对照试验是最有力的医学研究形式，可以改变医生的建议。随机对照试验可以比较接受不同治疗的患者的结果，或将新治疗与现有治疗或安慰剂（虚拟治疗）进行比较。研究人员将参与者随机分配到每个治疗组，以确保两组之间的比较在科学上是准确的，因为除了治疗之外的所有其他因素在每组中都可能具有可比性。尽管随机对照试验提供了良好的证据，但许多随机对照试验的设计和完成非常困难，例如，一些随机对照试验由于无法招募足够的患者而没有完成。其他随机对照试验没有开始，因为这些问题需要复杂的设计、实施和结果分析。MRC行为中心将专注于允许临床重要但过于困难的随机对照试验的研究。，才能成功进行。因此，该中心应该最终导致临床实践的改变，并根据最佳证据为医生和患者提供更好的信息，以选择哪种治疗方法。这将通过汇集具有不同研究背景的经验丰富的团队来开发执行随机对照试验的新方法来实现。该中心将由一名在NHS工作的外科医生指导，他已经开展了改进随机对照试验的研究。该中心的研究人员将与英国各地的其他MRC中心以及英格兰西南部和南威尔士的NHS组织合作开展这项工作。行为中心将根据六个研究主题提供短期课程和讲习班的培训计划。这将为设计和实施随机对照试验的研究人员和临床医生提供基础和高级学习机会。在专业研究领域提供新的课程和博士学位。总之，ConDuCT Hub将汇集研究人员和临床医生，以改进随机对照试验的设计。这将导致更多更好的随机对照试验的开始和完成。ConDuCT Hub将专注于解决有关最佳治疗方法的重要问题，并将为患者和医生决定使用哪种治疗方法提供更好的信息。