Development of contrast enhanced ultrasonography using the sheep ovarian model of microvascular regulation

利用绵羊卵巢微血管调节模型开发超声造影

• 批准号: G0800896/2
• 负责人: Vassilis Sboros
• 金额: $ 20.88万
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800896%2F2
• 关键词: Development; contrast; enhanced; ultrasonography; using

A large number of diseases, including cancer, infertility, heart and pregnancy abnormalities, depend on changes to the blood flow in the area of the disease. In cancer generally there is more blood flow generated by the cancer cells, while in heart attacks there is an area in the heart that almost has no blood supply. The seriousness of the disease is also linked to small blood flow changes. The ovary is a tissue where blood flow changes occur naturally during the menstrual cycle. Thus this tissue can simulate a range of diseases and can be used as a system for setting up an accurate blood flow measuring tool. Ultrasound imaging combined with contrast agents that are injected into the blood stream to assess the blood supply of small areas, would be a major advance in the diagnosis and treatment of many different diseases. We plan to develop the tools to do this by focussing on a small tissue in which the blood supply changes from very small to very large in a predictable reproducible way. We can also use drugs to change the blood supply to this tissue. This tissue is in the sheep ovary and if we can use this to create tools to measure normal and abnormal blood flow we can then take this tool directly into the clinic to measure the important changes to blood flow in a variety of important human diseases.

许多疾病，包括癌症、不孕不育、心脏和妊娠异常，都依赖于疾病区域血流的变化。在癌症中，通常癌细胞产生更多的血液流动，而在心脏病发作时，心脏中有一个区域几乎没有血液供应。这种疾病的严重性也与血液流动的微小变化有关。卵巢是一种组织，在月经周期中血液流动发生自然变化。因此，这种组织可以模拟一系列疾病，并可以用作设置准确的血流测量工具的系统。超声成像结合注射到血流中的造影剂来评估小区域的血液供应，将是许多不同疾病诊断和治疗的重大进步。我们计划开发工具来实现这一点，通过专注于一种小组织，其中的血液供应以可预测的可重复方式从非常小的变化到非常大的变化。我们也可以使用药物来改变这种组织的血液供应。这种组织在绵羊的卵巢中，如果我们可以利用它来创造工具来测量正常和异常的血流，我们就可以直接把这个工具带到临床上来测量各种重要人类疾病的血流的重要变化。