The Role of Notch-RFX Signaling in Ciliogenesis

Notch-RFX 信号在纤毛发生中的作用

• 批准号: G0802138/1
• 负责人: Aoife Waters
• 金额: $ 49.91万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802138%2F1
• 关键词: Role; Notch; RFX; Signaling; Ciliogenesis

Every organ in the body has unique functions which facilitates the body‘s ability to react to environmental stimuli. An organ is made up of cells with different characteristics which allow that organ to carry out its function. While all cells are initially derived from a single cell type, a programme of genes within a given cell can tell that cell what to become. Chemicals secreted by signal-sending cells can activate a programme of genes in neighbouring cells which receive the signal. As a result, proteins are made within the cell which interact with each other and carry out the special functions of that cell. Sensing changes in the environment is a unique cellular function that is undertaken by structures called cilia which project from the cell surface. Many diseases can result from processes which interfere with the synthesis and function of cilia. We, in the Beales laboratory aim to identify the chemical signals which instruct cells to make cilia. At the same time, we will be investigating genetic defects in a family with a rare cilia-related disease. This work has important implications for the treatment of a wide range of cilia-related diseases that include kidney failure, obesity and diabetes.

身体的每个器官都有独特的功能，可以提高身体对环境刺激做出反应的能力。器官由具有不同特征的细胞组成，这些特征使该器官能够发挥其功能。虽然所有细胞最初都源自单一细胞类型，但给定细胞内的基因程序可以告诉该细胞将成为什么。信号发送细胞分泌的化学物质可以激活接收信号的邻近细胞中的基因程序。结果，细胞内产生蛋白质，它们相互作用并执行该细胞的特殊功能。感知环境变化是一种独特的细胞功能，由从细胞表面突出的纤毛结构承担。许多疾病可能是由干扰纤毛合成和功能的过程引起的。我们在比尔斯实验室的目标是识别指导细胞产生纤毛的化学信号。与此同时，我们将调查一个患有罕见纤毛相关疾病的家庭的遗传缺陷。这项工作对于治疗多种纤毛相关疾病（包括肾衰竭、肥胖和糖尿病）具有重要意义。