STUDIES OF CHILDHOOD SOLID TUMORS

儿童实体瘤的研究

• 批准号: 3093032
• 负责人: ALEXANDER A. GREEN
• 金额: $ 93.7万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-08-01 至 1988-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093032
• 关键词: child (0-11); pediatric neoplasm /cancer

The ultimate objective of this program is the cure of children with cancer. The program is a coordinated effort of therapy and study which includes therapeutic trials, studies of tumor cell biology, and studies of the effects of therapy on normal tissues. The program consists of a core section and four projects. The core section provides for resource personnel, patient data base, biostatistics, and two resource laboratory functions - a tissue culture and cytogenetics laboratory and an animal xenograft developmental laboratory. The projects are: (1) neuroblastoma therapy and cell biology; (2) rhabdomyosarcoma: a laboratory model for pharmacological studies; (3) Ewing's sarcoma therapy and cell kinetics as well as features of biological behavior; (4) phase I and II trials of new agents for refractory tumors. All projects have the same ultimate objective through a variety of disciplines and approaches. The organizational structure provides the means for unified and coordinated effort.

该计划的最终目标是治愈患有 癌 该计划是一个治疗和研究的协调努力， 包括治疗试验、肿瘤细胞生物学研究以及 治疗对正常组织的影响。 该方案由一个核心 项目和四个项目。 核心部分提供资源 人员、患者数据库、生物统计学和两个资源实验室 组织培养和细胞遗传学实验室和动物 异种移植发育实验室 这些项目是：（1）神经母细胞瘤 治疗和细胞生物学;（2）横纹肌肉瘤：一个实验室模型， （3）尤文氏肉瘤的治疗和细胞动力学 以及生物学行为特征;（4）新的I期和II期试验 用于难治性肿瘤的药剂。 所有项目都有相同的终极目标 通过各种学科和方法来实现目标。 的 组织结构提供了统一和协调的手段， 努力