DIAGNOSTIC RADIOLOGY METHOD DEVELOPMENT RESEARCH

该计划的长期目标是开发新的诊断方法， 方法，并将其应用于临床诊断放射学。 一个主要 该提案的一部分致力于核磁共振成像，其中新的问题 随着新硬件的出现， 上线，新的结果就出来了。 光子辐射探测 在所有重要的“前端”， 技术. 一个新的项目探索了视觉上整合 快速发展的诊断成像领域所产生的信息。 具体而言，核磁共振成像的综合方法扩展到人类 大鼠组织表征方案，以证实结果， 提供一个数据库，以便优化技术， 临床疗效研究。 我们还建议研究实际问题， 核磁共振成像对磁场强度的依赖性， 核磁共振成像内源性元素的能力的问题， 氢气 第三个建议探讨了核磁共振在描述血液特征方面的应用 在毛细管床中流动。 各种技术已经证明 可行性，本项目从实用性和 结果的有效性。 并提出了对潜在危害的研究。 虽然我们期望核磁共振是一种良性的性质， 回答有关危害的问题。 的 由此产生的信息将增加NMR可以 将其应用于临床实践。 这里提出的另外两个项目 来自现有赠款资助的活动，是对 已被证明富有成效的技术，并将导致生产力 在未来的应用中继续。 其中第一个涉及 锗探测器制造中遇到的实际问题 用于成像设备。 解决这些问题将为 大大提高了核医学成像的可能性， 允许探索这些设备在其他诊断中的应用 地区 其中第二个项目探讨了小说和 不同的信息在共同的显示格式，希望最大限度地提高 从不同模式获得的信息被整合的信心 由医生。

The long term goals of the Program are to develop new diagnostic methodologies and to apply them to clinical diagnostic radiology. A major portion of the proposal is dedicated to NMR imaging, where new questions and research opportunities are opening up at a fast pace as new hardware comes on line and new results become available. Photon radiation detection technologies are also explored, in the all important "front end" technology. A new project explores means of visually integrating the information produced by the rapidly advancing field of diagnostic imaging. Specifically, an integrated approach to NMR imaging extends to humans protocols of tissue characterization in rats, to corroborate findings and provide a data base with which to optimize the technique and later initiate clinical efficacy studies. We also propose to study the practical question of dependence of NMR imaging on magnetic field strength and the scientific question of NMR's ability to image endogenous elements other than hydrogen. A third proposal explores the use of NMR in characterizing blood flow in the capillary bed. Various techniques have demonstrated feasibility, and this project explores them in terms of practicality and validity of results. The study of potential hazards is also proposed. Although we expect NMR to be of a benign nature, a practical approach towards answering questions regarding hazards has to be implemented. The information thus produced will increase the confidence with which NMR can be brought into clinical practice. The other two projects proposed here derive from existing grant-funded activities and represent an investment in technologies that have proven fruitful and which will lead to productive continuation in future applications. The first of these deals with the practical problems encountered in the fabrication of germanium detectors for imaging devices. Solving these problems will open up the way for vastly improved nuclear medicine imaging possibilities, and will also permit exploration of application of these devices in other diagnostic areas. The second of these projects explores the integration of novel and varied information in common display formats, hoping to maximize the confidence with which the information from varied modalities is integrated by the physician.