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STRUCTURE AND BIOSYNTHESIS OF PROTEOGLYCANS

STRUCTURE AND BIOSYNTHESIS OF PROTEOGLYCANS
蛋白聚糖的结构和生物合成
批准号：
3963697
负责人：
V C HASCALL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3963697
关键词：
bacterial polysaccharides chondrocytes chromatography corneal stroma endotoxins epithelium genetic strain hyaluronate keratan sulfate lipopolysaccharides oligosaccharides organ culture ovary phase change proteoglycan retinoids skin tissue /cell culture ultracentrifugation

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中文摘要
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英文摘要
The purpose of the project is to study the chemical and physical properties and biosynthesis of proteoglycans in a number of tissue and cell systems. Topics of present interest include: 1) Protein chemistry and immunology of the hyaluronic acid-binding region of proteoglycans from the Swarm rat chondrosarcoma; 2) Biosynthesis of core protein precursors and processing to mature proteoglycans; 3) Metabolism of proteoglycans by rat ovarian granulosa cells; 4) Effects of bacterial endotoxins (lipopolysaccharides) and interleukin 1 on the regulation of proteoglycan metabolism in organ cultures of bovine articular cartilages; 5) Characterization of the keratan sulfate-proteoglycan and dermatan sulfate-proteoglycan in cornea.
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STRUCTURE AND BIOSYNTHESIS OF PROTEOGLYCANS
STRUCTURE AND BIOSYNTHESIS OF PROTEOGLYCANS
NOVEL METHODS FOR ANALYZING GLYCOSMINOGLYCAN SUBSTRUCTURE
HYALURONIC ACID SYNTHESIS BY OVARIAN CUMULUS AND GRANULOSA CELLS
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