A new mechanism of tissue fibrosis - a small peptide regulator of the TGF-beta1/Smad pathway

组织纤维化的新机制——TGF-β1/Smad通路的小肽调节剂

• 批准号: nhmrc : 2003019
• 金额: $ 76.88万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/a-new-mechanism-beta1smad-pathway/1780056
• 关键词: new; mechanism; tissue; fibrosis; small

Progressive scarring, or fibrosis, of organs leads to their loss of function. Fibrotic diseases are devastating to both the individual and our community and we lack effective therapies. We have identified a small protein, named SPRF, which represents a new mechanism in tissue fibrosis. These studies will examine the role of the SRPF protein in models of kidney, heart and lung fibrosis and its underlying mechanism of action. We will also test a therapy based on inhibiting SPRF function.

器官的进行性瘢痕形成或纤维化导致其功能丧失。纤维化疾病对个人和社区都是毁灭性的，我们缺乏有效的治疗方法。我们发现了一种小蛋白，命名为SPRF，它代表了组织纤维化的一种新机制。这些研究将检查SRPF蛋白在肾脏、心脏和肺纤维化模型中的作用及其潜在的作用机制。我们还将测试一种基于抑制SPRF功能的疗法。