Elucidating the role of JAM-B in breast cancer and angiogenesis

阐明 JAM-B 在乳腺癌和血管生成中的作用

• 批准号: G0901609/1
• 负责人: Kairbaan Hodivala-Dilke
• 金额: $ 47.73万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901609%2F1
• 关键词: Elucidating; role; JAM; breast; cancer

Breast cancer is the most common cancer in women in the UK, but how angiogenesis is regulated in breast cancer is unknown. The growth of blood vessels into tumours (angiogenesis) is essential for cancer growth, and anti-angiogenic therapy is an important new strategy to treat cancer. Interestingly, women with Down Syndrome very rarely develop breast cancer, possibly as a result of the presence of three copies of chromosome 21. We will determine how three copies of chromosome 21 suppresses breast cancer angiogenesis. I will focus upon the involvement of a specific chromosome 21 molecule, termed JAM-B, which we already have evidence for a role in angiogenesis. I will use both clinical material and experimental mouse models. This research will help us to understand the disease better and possibly lead to the development of therapies to inhibit breast cancer progression.

乳腺癌是英国女性最常见的癌症，但乳腺癌中血管生成是如何调控的还不清楚。血管向肿瘤的生长(血管生成)是肿瘤生长所必需的，而抗血管生成治疗是治疗癌症的重要新策略。有趣的是，患有唐氏综合症的女性很少患上乳腺癌，这可能是因为21号染色体存在三个副本。我们将确定21号染色体的三个拷贝如何抑制乳腺癌血管生成。我将重点介绍一种特殊的21号染色体分子，称为JAM-B，我们已经有证据表明它在血管生成中起到了作用。我将同时使用临床材料和实验小鼠模型。这项研究将帮助我们更好地了解这种疾病，并可能导致抑制乳腺癌进展的治疗方法的开发。