Determinants of visit-to-visit variability in blood pressure and the related risks of stroke and dementia.

这项研究将涉及短暂性脑缺血发作(“微中风”)或轻微中风后的患者，他们接受了独特的详细血压监测和大脑成像。它的目的是找出为什么一些患者的血压每天的变化比其他患者更大，以及为什么这会导致更高的中风和发展为痴呆症的机会。患者将接受静息状态下血管僵硬和反应性的非侵入性测量，以及对自发和诱发的血压变化的测量。这些测量将与血压的日常和其他类型的变异性、大脑成像以及患中风或痴呆症的长期风险有关。我有独一无二的机会来做这项研究，这是牛津中风预防研究组与心血管医学部合作进行的研究计划的一部分。这一结果应该会增加我们对血压变异性的理解--血压变异性是中风和血管性痴呆症的主要新风险因素。

This study will involve patients following a TIA (‘mini-stroke‘) or small stroke who have undergone uniquely detailed monitoring of their blood pressure and imaging of their brains. It will aim to work out why some patients‘ blood pressure varies from day-to-day more than other patients, and why this results in a higher chance of having a stroke and of developing dementia. Patients will undergo non-invasive measurements of the stiffness and reactivity of their blood vessels at rest and to spontaneous and induced changes in blood pressure. These measures will be related to day-to-day and other types of variability in blood pressure, imaging of their brains, and the long-term risk of developing stroke or dementia. I have the unique opportunity to do this study as part of an ongoing programme of research in the Stroke Prevention Research Unit in Oxford, in collaboration with the Department of Cardiovascular Medicine. The results should increase our understand of variability in blood pressure - a major new risk factor for stroke and vascular dementia.