Determinants of visit-to-visit variability in blood pressure and the related risks of stroke and dementia.

血压每次访视变异性的决定因素以及中风和痴呆的相关风险。

• 批准号: G1000372/1
• 负责人: Alastair Webb
• 金额: $ 25.29万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000372%2F1
• 关键词: Determinants; visit; variability; blood; pressure

This study will involve patients following a TIA (‘mini-stroke‘) or small stroke who have undergone uniquely detailed monitoring of their blood pressure and imaging of their brains. It will aim to work out why some patients‘ blood pressure varies from day-to-day more than other patients, and why this results in a higher chance of having a stroke and of developing dementia. Patients will undergo non-invasive measurements of the stiffness and reactivity of their blood vessels at rest and to spontaneous and induced changes in blood pressure. These measures will be related to day-to-day and other types of variability in blood pressure, imaging of their brains, and the long-term risk of developing stroke or dementia. I have the unique opportunity to do this study as part of an ongoing programme of research in the Stroke Prevention Research Unit in Oxford, in collaboration with the Department of Cardiovascular Medicine. The results should increase our understand of variability in blood pressure - a major new risk factor for stroke and vascular dementia.

这项研究将涉及TIA（“小中风”）或小中风后的患者，这些患者接受了独特的详细血压监测和大脑成像。它的目标是找出为什么一些患者的血压每天变化比其他患者更大，以及为什么这会导致中风和痴呆症的几率更高。患者将接受无创性测量，测量其血管在静息时以及对自发和诱导血压变化的硬度和反应性。这些措施将与日常和其他类型的血压变化，大脑成像以及患中风或痴呆症的长期风险有关。我有一个独特的机会来做这项研究，作为牛津大学中风预防研究中心正在进行的研究计划的一部分，与心血管医学系合作。这些结果应该会增加我们对血压变异性的理解--这是中风和血管性痴呆的一个主要的新危险因素。