S Norris University of the Witwatersrand Health and wellbeing of female adolescents and young adults

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A major challenge in sub-Saharan Africa is the complex relationship between poor maternal nutrition and postnatal stunting on one hand and the increased risk of adolescent and adult obesity on the other leading to an increased risk of type-2 diabetes (T2D) and metabolic disease in future generations. The proposed studies of contemporary urban and rural South African adolescent and young adults (generation 1) and their offspring (generation 2) will provide a unique opportunity to evaluate outcomes relating to risk factors for T2D and metabolic disease that are transmistted across generations. Primary research question relates to the effects of adolescent weight gain, pregnancy risk for T2D, and subsequent offspring disease risk.