S Norris University of the Witwatersrand Health and wellbeing of female adolescents and young adults

威特沃特斯兰德诺里斯大学 女性青少年和年轻人的健康与福祉

• 批准号: G1001333/1
• 负责人: David Dunger
• 金额: $ 239.53万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001333%2F1
• 关键词: Norris; University; Witwatersrand; Health; wellbeing

A major challenge in sub-Saharan Africa is the complex relationship between poor maternal nutrition and postnatal stunting on one hand and the increased risk of adolescent and adult obesity on the other leading to an increased risk of type-2 diabetes (T2D) and metabolic disease in future generations. The proposed studies of contemporary urban and rural South African adolescent and young adults (generation 1) and their offspring (generation 2) will provide a unique opportunity to evaluate outcomes relating to risk factors for T2D and metabolic disease that are transmistted across generations. Primary research question relates to the effects of adolescent weight gain, pregnancy risk for T2D, and subsequent offspring disease risk.

撒哈拉以南非洲面临的一项重大挑战是，一方面孕产妇营养不良和产后发育迟缓，另一方面青少年和成人肥胖风险增加，导致后代患2型糖尿病和代谢性疾病风险增加，两者之间存在复杂关系。对当代城市和农村南非青少年和年轻人（第一代）及其后代（第二代）的拟议研究将提供一个独特的机会来评估与跨代传播的T2D和代谢性疾病风险因素相关的结果。主要研究问题涉及青少年体重增加、妊娠期T2D风险以及随后的后代疾病风险的影响。