Top Jabs - Improving vaccination responses in older adults

热门疫苗接种 - 改善老年人的疫苗接种反应

• 批准号: G1001390/1
• 负责人: Kai-Michael Toellner
• 金额: $ 81.81万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001390%2F1
• 关键词: Top; Jabs; Improving; vaccination; responses

Older adults are more likely to get infections than young people, which is why the NHS vaccinates against the ?flu and pneumonia because of immune system ageing. Unfortunately, as people age, their body?s immune system works less well, meaning that responses to vaccination are less able to protect against illness. It is important to better understand why older people have poorer vaccine responses and to improve these. We plan to research this in older animals and humans. We will look at the processes involved in making high quality antibodies in mice, and test three ways of improving the vaccination response in mice and humans ? adding to vaccine components; improving people?s sensitivity to insulin; or simply changing the time of day when vaccines are given.

老年人比年轻人更容易受到感染，这就是为什么英国国家医疗服务体系（NHS）要接种疫苗预防麻疹的原因。流感和肺炎是因为免疫系统老化。不幸的是，随着人们年龄的增长，他们的身体？美国人的免疫系统工作不太好，这意味着对疫苗接种的反应不太能够预防疾病。重要的是要更好地了解为什么老年人的疫苗反应较差并加以改善。我们计划在老年动物和人类身上进行研究。我们将研究在小鼠体内制造高质量抗体的过程，并测试三种改善小鼠和人类疫苗接种反应的方法。添加到疫苗成分中；改善人们吗?S对胰岛素敏感性；或者只是改变一天中接种疫苗的时间。