THE PATHOPHYSIOLOGY OF THE ALCOHOL WITHDRAWAL SYNDROME

在这个项目中，我们探索了两个重要的致病机制(S) 慢性酒精中毒患者临床常见问题分析 戒断：(1)睡眠-觉醒周期紊乱，(2)增加 易受感染。24小时人体测量 体温、运动、动态脑电和尿儿茶酚胺 对急性戒酒的人进行排泄 停药后及停药后3周。血浆褪黑激素、皮质醇和 ACTH将每隔3小时测定一次，手部震颤将 反复测量。卧床去甲肾上腺素测定将是 在最初的72小时内做两次，每周一次，持续3周。 酒精中毒患者和年龄和性别匹配的对照组将被评估 确定长期饮酒影响的一般免疫成分 滥用和戒酒对免疫系统的影响。病人将会是 定期评估，以调查不同持续时间的影响 戒酒对选定的免疫能力参数的影响。

In this project, we explore the etiologic mechanism(s) of two important clinical problems frequently observed in the chronic alcoholic during withdrawal: (1) disturbed sleep-wake cycle, and (2) increased susceptibility to infection. Twenty-four hour measurements of body temperature, motor activity, ambulatory EEG, and urinary catecholamine excretion will be performed on acutely withdrawing alcoholics during withdrawal and 3 weeks after withdrawal. Plasma melatonin, cortisol, and ACTH will be determined at 3-hour intervals, and hand tremor will be repeatedly measured. Lying-standing norepinephrine determinations will be made twice during the initial 72 hours and once weekly for 3 weeks. Alcoholic patients and age- and sex-matched controls will be evaluated for general immunocomponents to determine the effects of long-term alcohol abuse and withdrawal from alcohol on the immune system. Patients will be evaluated at regular intervals to investigate effects of varying durations of abstinence from alcohol on selected parameters of immunocompetency.