THE PATHOPHYSIOLOGY OF THE ALCOHOL WITHDRAWAL SYNDROME

在这个项目中，我们探讨了两个重要的致病机制， 慢性酒精中毒中常见的临床问题 戒断：（1）睡眠-觉醒周期紊乱，（2）增加 对感染的易感性 24小时身体测量 体温、运动活动、动态EEG和尿儿茶酚胺 排泄将在急性戒酒期间进行， 停药和停药后3周。 血浆褪黑激素，皮质醇， 每隔3小时测定一次ACTH， 反复测量。 卧位-站立位去甲肾上腺素测定将 在最初的72小时内进行两次，每周一次，持续3周。 将对酒精中毒患者和年龄和性别匹配的对照组进行评估， 一般免疫成分，以确定长期酒精的影响 滥用和戒酒对免疫系统的影响。 患者将 定期评估，以调查不同持续时间的影响 对免疫功能参数的影响。

In this project, we explore the etiologic mechanism(s) of two important clinical problems frequently observed in the chronic alcoholic during withdrawal: (1) disturbed sleep-wake cycle, and (2) increased susceptibility to infection. Twenty-four hour measurements of body temperature, motor activity, ambulatory EEG, and urinary catecholamine excretion will be performed on acutely withdrawing alcoholics during withdrawal and 3 weeks after withdrawal. Plasma melatonin, cortisol, and ACTH will be determined at 3-hour intervals, and hand tremor will be repeatedly measured. Lying-standing norepinephrine determinations will be made twice during the initial 72 hours and once weekly for 3 weeks. Alcoholic patients and age- and sex-matched controls will be evaluated for general immunocomponents to determine the effects of long-term alcohol abuse and withdrawal from alcohol on the immune system. Patients will be evaluated at regular intervals to investigate effects of varying durations of abstinence from alcohol on selected parameters of immunocompetency.