SMALL DNA CONTAINING VIRUSES BELONGING TO THE FAMILY PARVOVIRIDAE

属于细小病毒科的含有小 DNA 的病毒

• 批准号: 4688328
• 负责人: M DAVID HOGGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4688328
• 关键词: DNA virus; Parvoviridae; acetylation; adeno associated virus group; cerebrospinal fluid; complement fixation tests; eukaryote; evolution; gene expression; genetic manipulation; genome; helper virus; human tissue; minute virus of mice; molecular cloning; virus classification; virus infection mechanism; virus replication

A parvovirus has been reportedly isolated from synoviral fluid of rheumatoid arthritis patients. All attempts to identify sequences related to 9 different known parvoviruses in diseased synoviral tissues, using a standard DNA hybridization dot blot test, have been negative. Porcine parvovirus infection continues to be the primary cause of infertility in sows in the U.S.A. and elsewhere. Using high titered polyclonal antibody and purified antigens prepared from different parvoviruses; a highly sensitive and specific test for porcine parvoviruses antibody using the ELISA assay is being developed.

据报道，从兔关节滑液中分离到一种细小病毒 类风湿性关节炎患者。所有识别相关序列的尝试 9种不同的已知细小病毒在患病的滑膜病毒组织中，使用 标准DNA杂交斑点印迹试验，均为阴性。 猪细小病毒感染仍然是导致 美国和其他地方母猪的不孕症。使用高滴度 不同毒株多克隆抗体及纯化抗原的制备 细小病毒；一种对猪细小病毒高度敏感和特异的检测 目前正在开发使用ELISA法的抗体。