Role of ARID1A in endometrial proliferation, endometriosis and endometriosis-associated ovarian cancer pathogenesis

ARID1A在子宫内膜增殖、子宫内膜异位症和子宫内膜异位症相关卵巢癌发病机制中的作用

• 批准号: G1001957/1
• 负责人: Ioannis Gounaris
• 金额: $ 32.52万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001957%2F1
• 关键词: Role; ARID1A; endometrial; proliferation; endometriosis

Ovarian cancer is one of the leading causes of death from cancer in women. There are 4 major types of ovarian cancer. The clear-cell and endometrioid types of ovarian cancer are related to a condition called endometriosis. The latter is a common cause of pelvic pain and infertility. Clear-cell cancer in particular, is very difficult to treat when it has spread because currently available chemotherapies are not effective. Recent research has identified a gene, called ARID1A, which appears to play a role in these two types of ovarian cancer. Specifically, mutations of this gene are found in approximately a third of endometrioid cancers and a half of clear cell cancers as well as in endometriosis. This research project aims to find out how mutations in ARID1A cause cancer. This will involve testing the effects of the mutation on growth and hormonal control in cells cultured in a petri dish. It will also involve experiments in mice that have this gene mutation. If we are able to understand better how this mutation causes cancer, then we will be able to design better treatments that will allow these patients to live longer or have less symptoms.

卵巢癌是女性癌症死亡的主要原因之一。卵巢癌有 4 种主要类型。卵巢癌的透明细胞癌和子宫内膜样癌与子宫内膜异位症有关。后者是盆腔疼痛和不孕的常见原因。特别是透明细胞癌，当其扩散时非常难以治疗，因为目前可用的化疗无效。最近的研究发现了一种名为 ARID1A 的基因，它似乎在这两种类型的卵巢癌中发挥着作用。具体来说，大约三分之一的子宫内膜样癌和一半的透明细胞癌以及子宫内膜异位症中发现了该基因的突变。该研究项目旨在找出 ARID1A 突变如何导致癌症。这将涉及测试突变对培养皿中培养的细胞的生长和激素控制的影响。它还将涉及对具有这种基因突变的小鼠进行实验。如果我们能够更好地了解这种突变如何导致癌症，那么我们将能够设计出更好的治疗方法，让这些患者活得更长或症状更少。