Systematic Techniques for Assessing Recruitment to Trials (START): a programme to test recruitment interventions

评估试验招募的系统技术 (START)：测试招募干预措施的计划

• 批准号: G1002325/1
• 负责人: Peter Bower
• 金额: $ 70.21万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002325%2F1
• 关键词: Systematic; Techniques; Assessing; Recruitment; Trials

The best way to test new treatments is to see how well they work in a randomised controlled trial (RCT). This means some patients get the treatment and some do not, and the results of the different groups are compared to see if the treatment leads to better health. Although many trials like this are run in the NHS, recruiting patients to these trials is often difficult and takes longer than planned. This means that research is delayed and that patients and professionals cannot benefit from the knowledge about what treatments work best. Our aim is to develop new ways of helping to recruit patients to trials, and to test them in randomised controlled trials that are ongoing in the NHS. To achieve this, we will do three things:(a) We will develop methods to help us test recruitment methods, by looking at the published work worldwide and exploring different statistical issues(b) We will develop new methods to help patients take part in trials, such as new ways of providing information to patients to help them understand randomised controlled trials(c) We will work with researchers who are running trials in primary care and community settings, helping them to use our new patient information with their patients. We will collect data from these trials and test whether our new methods improve recruitment ratesAs well as testing our new methods, we hope our work will help us to understand how best to test recruitment methods in trials, and will encourage researchers in the future to get involved in such testing. This will help the NHS to do research and use the knowledge to improve the health and well being of patients.

测试新疗法的最佳方法是观察它们在随机对照试验 (RCT) 中的效果如何。这意味着有些患者得到了治疗，有些则没有，并且比较不同组的结果，看看治疗是否会带来更好的健康。尽管许多类似的试验是在 NHS 中进行的，但招募患者参加这些试验通常很困难，并且需要比计划更长的时间。这意味着研究被推迟，患者和专业人士无法从了解哪种治疗效果最好的知识中受益。我们的目标是开发新方法来帮助招募患者参加试验，并在 NHS 正在进行的随机对照试验中对他们进行测试。为了实现这一目标，我们将做三件事：（a）我们将开发方法来帮助我们测试招募方法，通过查看世界范围内已发表的工作并探索不同的统计问题（b）我们将开发新方法来帮助患者参与试验，例如向患者提供信息以帮助他们理解随机对照试验的新方法（c）我们将与在初级保健和社区环境中进行试验的研究人员合作，帮助他们将我们的新患者信息用于患者。我们将从这些试验中收集数据，并测试我们的新方法是否可以提高招募率。在测试我们的新方法的同时，我们希望我们的工作能够帮助我们了解如何最好地在试验中测试招募方法，并鼓励研究人员在未来参与此类测试。这将有助于 NHS 进行研究并利用知识来改善患者的健康和福祉。