The role of Nrf2 (nuclear factor erythroid 2 related factor 2) in the cardiac response to chronic overload stress.

Nrf2（核因子红细胞 2 相关因子 2）在心脏对慢性超负荷应激反应中的作用。

• 批准号: G1100441/1
• 负责人: Adam Nabeebaccus
• 金额: $ 28.58万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100441%2F1
• 关键词: role; Nrf2; nuclear; factor; erythroid

Heart failure is a leading cause of morbidity and mortality. New treatments are required to address this growing problem. Understanding the mechanisms involved in the development of heart failure is the key to developing new treatments. When a heart is under prolonged stress, such as high blood pressure, it initially adapts to preserve its function. However, with time, its strength declines and heart failure ensues. A complex interplay between protective and damaging cellular pathways determines whether the heart adapts or fails. This project will study the role of a master regulator of genes, known as Nrf2, which we believe may play a key role in activating protective pathways in the heart. The project will study the role of Nrf2 in protecting the heart during exposure to chronic high blood pressure and will investigate the pathways activated by Nrf2 that are involved in such protection. By using state-of-the-art methodology to analyse the complex changes coordinated and regulated by Nrf2, we hope that the project will provide novel insights into key mechanisms involved in the development of heart failure and therefore lead to the identification of novel therapeutic targets for this debilitating condition.

心力衰竭是发病率和死亡率的主要原因。需要新的治疗方法来解决这个日益严重的问题。了解心力衰竭发生的机制是开发新治疗方法的关键。当心脏处于长时间的压力下时，如高血压，它最初会适应以保持其功能。然而，随着时间的推移，其强度下降，心力衰竭加重。保护性和破坏性细胞通路之间的复杂相互作用决定了心脏是适应还是衰竭。该项目将研究基因的主要调节因子Nrf2的作用，我们认为它可能在激活心脏保护途径中发挥关键作用。该项目将研究Nrf2在暴露于慢性高血压期间保护心脏的作用，并将研究参与这种保护的Nrf2激活的途径。通过使用最先进的方法来分析Nrf2协调和调节的复杂变化，我们希望该项目将为心力衰竭发展中涉及的关键机制提供新的见解，从而为这种衰弱性疾病确定新的治疗靶点。