PHARMACOKINETICS & NEUROENDOCRINE EVALUATION OF M-CHLOROPHENYL PIPERAZINE

最近的研究表明，5-羟色胺激动剂间氯苯基哌嗪 (曲唑酮的代谢物)调节吲哚胺系统并产生 激动剂对神经内分泌和体温调节脑的影响 系统。因为这是m-cpp给出的第一次调查。 通过静脉注射，一项研究旨在评估其在正常情况下的处置情况 健康对照组。脉搏和血压正在被监测， 皮质醇和催乳素水平评估副作用和动态反应 药物的作用。 由于正在评估最大耐受剂量，我们已继续进行 M-cpp在猕猴体内的处置评价。我们已经完成了分析 用一种新开发的简单的高效液相定量方法测定6只猴子的样本 采用单次提取和电化学检测器的程序。 该方法的灵敏度可达0.5 ng/m1。

Recent studies have shown that serotonin agonist, m-chlorophenyl piperazine (a metabolite of trazodone) modulates the indoleamine system and produces agonist effects on neuroendocrine and temperature regulating brain systems. As this is the first investigation m-CPP when given intravenously, a study was designed to evaluate its disposition in normal healthy controls. Pulse and blood pressure are being monitored along with cortisol and prolactin levels to evaluate side effects and dynamic response of the drug. As the maximum tolerated dose is being assessed, we have proceeded with the evaluation of m-CPP disposition in monkeys. We have finished analyzing samples from 6 monkeys using a simple, newly developed HPLC quantitation procedure that employs single extraction and an electrochemical detector. A sensitivity of 0.5 ng/m1 can be achieved with this procedure.