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CELL AND MOLECULAR BIOLOGY OF GLOMERULAR CELLS DERIVED FROM TRANSGENIC MICE

CELL AND MOLECULAR BIOLOGY OF GLOMERULAR CELLS DERIVED FROM TRANSGENIC MICE
转基因小鼠肾小球细胞的细胞和分子生物学
批准号：
4689979
负责人：
G E STRIKER
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689979
关键词：
cell growth regulation clone cells extracellular matrix genome growth media kidney cell metallothionein microinjections molecular genetics plasmids renal glomerulus simian virus 40

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英文摘要
omeruli of transgenic mice developing from eggs microinjected with plasmids ntaining the SV40 early region genes and metallothionins fusion gene will isolated and ex-planted. The individual glomerular cells will be olated, cloned, and brought to confluence. The characteristics of the oned glomerular cells from transgenic and their non-transgenic litter mates ll be studied for their ability to proliferate, their growth in a defined sement membrane matrix, and for their synthesis of extracellular matrix oducts. Their response to various inflammatory mediators will also be vestigated.
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STUDIES OF GLOMERULAR CELLS DERIVED FROM NORMAL AND TRANSGENIC MICE
MORPHOMETRY OF THE GLOMERULUS IN PIMAS AND OTHER MINORITY POPULATIONS
STUDIES OF GLOMERULAR CELLS DERIVED FROM TRANSGENIC MICE
PENTOSAN POLYSULFATE IN TREATMENT OF CHRONIC VASCULAR DISEASE
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