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MRC/UVRI Medical Informatics Centre

MRC/UVRI 医学信息中心

基本信息

批准号：
MC_EX_MR/L016273/1
负责人：
Pontiano Kaleebu
金额：
$ 360.66万
依托单位：
Uganda Virus Research Institute
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MC_EX_MR%2FL016273%2F1
关键词：
MRC UVRI Medical Informatics Centre

项目摘要

Collating information on human health and disease, and understanding the biological processes that may cause disease can help identify ways to develop new treatments for these diseases. The use of complex statistics, computational resources and genetic information has greatly facilitated our understanding of human disease. For Africa to fully benefit from the technological advances in computing and ways to store and manage "big scientific data", we will need to ensure that African researchers have access to such resources locally. As part of an international collaboration, we aim to build a computational network and resource in Uganda, and train the next generation of African computer scientists as part of this initiative. This project will help facilitate our understanding on diseases in Africa and also provide a way to assess changes in the prevalence of these diseases, including HIV and other chronic diseases such as diabetes.

整理有关人类健康和疾病的信息，并了解可能导致疾病的生物过程，可以帮助确定开发这些疾病新疗法的方法。复杂的统计数据、计算资源和遗传信息的使用极大地促进了我们对人类疾病的理解。为了使非洲充分受益于计算技术进步以及储存和管理“大科学数据”的方法，我们需要确保非洲研究人员能够在当地获得这些资源。作为国际合作的一部分，我们的目标是在乌干达建立一个计算网络和资源，并培训下一代非洲计算机科学家。该项目将有助于促进我们对非洲疾病的了解，并提供一种方法来评估这些疾病，包括艾滋病毒和糖尿病等其他慢性病流行率的变化。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans.

DOI：
10.1093/hmg/ddab088
发表时间：
2021-07-28
期刊：
Human molecular genetics
影响因子：
3.5
作者：
Fatumo S;Chikowore T;Kalyesubula R;Nsubuga RN;Asiki G;Nashiru O;Seeley J;Crampin AC;Nitsch D;Smeeth L;Kaleebu P;Burgess S;Nyirenda M;Franceschini N;Morris AP;Tomlinson L;Newton R
通讯作者：
Newton R

Phylogenetic Networks and Parameters Inferred from HIV Nucleotide Sequences of High-Risk and General Population Groups in Uganda: Implications for Epidemic Control.

DOI：
10.3390/v13060970
发表时间：
2021-05-24
期刊：
Viruses
影响因子：
0
作者：
Bbosa N;Ssemwanga D;Nsubuga RN;Kiwanuka N;Bagaya BS;Kitayimbwa JM;Ssekagiri A;Yebra G;Kaleebu P;Leigh-Brown A
通讯作者：
Leigh-Brown A

Main Routes of Entry and Genomic Diversity of SARS-CoV-2, Uganda.

乌干达 SARS-CoV-2 的主要进入途径和基因组多样性。

DOI：
10.3201/eid2610.202575
发表时间：
2020-10
期刊：
Emerging infectious diseases
影响因子：
11.8
作者：
Bugembe DL;Kayiwa J;Phan MVT;Tushabe P;Balinandi S;Dhaala B;Lexow J;Mwebesa H;Aceng J;Kyobe H;Ssemwanga D;Lutwama J;Kaleebu P;Cotten M
通讯作者：
Cotten M

SARS-CoV-2 Variants, South Sudan, January-March 2021.

DOI：
10.3201/eid2712.211488
发表时间：
2021-12
期刊：
Emerging infectious diseases
影响因子：
11.8
作者：
Bugembe DL;Phan MVT;Abias AG;Ayei J;Deng LL;Lako RLL;Rumunu J;Kaleebu P;Wamala JF;Hm JJ;Lodiongo DK;Bunga S;Cotten M
通讯作者：
Cotten M

Emergence and spread of a SARS-CoV-2 lineage A variant (A.23.1) with altered spike protein in Uganda.

DOI：
10.1038/s41564-021-00933-9
发表时间：
2021-08
期刊：
Nature microbiology
影响因子：
28.3
作者：
Bugembe DL;Phan MVT;Ssewanyana I;Semanda P;Nansumba H;Dhaala B;Nabadda S;O'Toole ÁN;Rambaut A;Kaleebu P;Cotten M
通讯作者：
Cotten M

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Pontiano Kaleebu其他文献

Immune system and reproductive success: the genetics of the maternal-fetal interface

DOI：
10.1016/j.placenta.2014.06.190
发表时间：
2014-09-01
期刊：
Conference abstract
影响因子：
作者：
Olympe Chazara;Annettee Nakimuli;Lydia Farrell;Susan Hiby;Hugo Hilton;Paul Norman;Neda Nemat-Gorgani;Alison Eliott;Pontiano Kaleebu;Florence Mirembe;Peter Parham;Ashley Moffett
通讯作者：
Ashley Moffett

Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing

利用宏基因组测序揭示乌干达未确诊急性发热疾病的病毒病因

DOI：
10.1038/s41467-025-57696-8
发表时间：
2025-03-23
期刊：
Nature Communications
影响因子：
15.700
作者：
Shirin Ashraf;Hanna Jerome;Daniel Lule Bugembe;Deogratius Ssemwanga;Timothy Byaruhanga;John Timothy Kayiwa;Robert Downing;Jesus F. Salazar-Gonzalez;Maria G. Salazar;James G. Shepherd;Craig Wilkie;Chris Davis;Nicola Logan;Sreenu B. Vattipally;Gavin S. Wilkie;Ana da Silva Filipe;Alfred Ssekagiri;Prossy Namuwulya;Henry Bukenya;Brian K. Kigozi;Weronika Witkowska McConnell;Brian J. Willett;Stephen Balinandi;Julius Lutwama;Pontiano Kaleebu;Josephine Bwogi;Emma C. Thomson
通讯作者：
Emma C. Thomson

Afri-Can Forum 2

DOI：
10.1186/s12879-016-1466-6
发表时间：
2016-07-12
期刊：
BMC INFECTIOUS DISEASES
影响因子：
3.000
作者：
Hillary Mukudu;Neil Martinson;Benn Sartorius;Jenny Coetzee;Janan Dietrich;Kgaugelo Mokgatswana;Rachel Jewkes;Glenda E. Gray;Marylène Dugas;Luc Béhanzin;Fernand A. Guédou;Marie-Pierre Gagnon;Michel Alary;Rwamahe Rutakumwa;Martin Mbonye;Thadeus Kiwanuka;Sarah Nakamanya;Richard Muhumuza;Winfred Nalukenge;Janet Seeley;Millicent Atujuna;Melissa Wallace;Ben Brown;Linda Gail Bekker;Peter A. Newman;Rushil Harryparsad;Abraham J. Olivier;Heather B. Jaspan;Douglas Wilson;Janan Dietrich;Neil Martinson;Hillary Mukudu;Nonhlanhla Mkhize;Lynn Morris;Gianguido Cianci;Minh Dinh;Thomas Hope;Jo-Ann S. Passmore;Clive M. Gray;Bethany M. Henrick;Xiao-Dan Yao;Kenneth L. Rosenthal;Bethany M. Henrick;Xiao-Dan Yao;Anna G. Drannik;Alash’le Abimiku;Kenneth L. Rosenthal;Nadia Chanzu;Walter Mwanda;Julius Oyugi;Omu Anzala;Moustapha Mbow;Sabelle Jallow;Moussa Thiam;Alberta Davis;Assane Diouf;Cheikh T. Ndour;Moussa Seydi;Tandakha N. Dieye;Souleymane Mboup;Martin Goodier;Eleanor Rilley;Assan Jaye;Xiao-Dan Yao;RW. Omange;Bethany M. Henrick;Richard T. Lester;Joshua Kimani;T. Blake Ball;Francis A. Plummer;Kenneth L. Rosenthal;Luc Béhanzin;Fernand A. Guédou;Nassirou Geraldo;Ella Goma Mastétsé;Jerôme Charles Sossa;Marcel Djimon Zannou;Michel Alary;Sophia Osawe;Evaezi Okpokoro;Felicia Okolo;Stephen Umaru;Rebecca Abimiku;Sam Audu;Pam Datong;Alash’le Abimiku;Jacquelyn Nyange;Joyce Olenja;Gaudensia Mutua;Walter Jaoko;Gloria Omosa-Manyonyi;Bashir Farah;Maureen Khaniri;Omu Anzala;Anne Cockcroft;Kendra Tonkin;Indu Girish;Puna Mhati;Ashley Cunningham;Neil Andersson;Bashir Farah;Jackton Indangasi;Walter Jaoko;Gaudensia Mutua;Maureen Khaniri;Jacquelyn Nyange;Omu Anzala;Thabo Diphoko;Simani Gaseitsiwe;Victoria Maiswe;Thato Iketleng;Dorcas Maruapula;Keabetswe Bedi;Sikhulile Moyo;Rosemary Musonda;Mark Wainberg;Joseph Makhema;Vladimir Novitsky;Richard Marlink;Max Essex;Stephen Okoboi;Livingstone Ssali;Sam Kalibala;Josephine Birungi;Aggrey Egessa;Jonathan Wangisi;Lyavala Joanne Okullu;Celestin Bakanda;Francis Obare;I. Marion Sumari-de Boer;Hadija H. Semvua;Jossy van den Boogaard;Krisanta W. Kiwango;Kennedy M. Ngowi;Pythia T. Nieuwkerk;Rob E. Aarnoutse;Ireen Kiwelu;Eva Muro;Gibson S. Kibiki;Ruth Datiri;Grace Choji;Sophia Osawe;Evaezi Okpokoro;Felicia Okolo;Stephen Umaru;Rebecca Abimiku;Samuel Audu;Pam Datong;Alash’le Abimiku;A. Fomsgaard;I. Karlsson;K. J. Jensen;S. S. Jensen;C. Leo-Hansen;S. Jespersen;D. Da Silva Té;C. M. Rodrigues;Z. J. da Silva;C. M. Janitzek;J. Gerstoft;G. Kronborg;Evaezi Okpokoro;Sophia Osawe;Ruth Daitiri;Grace Choji;Stephen Umaru;Felicia Okolo;Pam Datong;Alash’le Abimiku;Nyariki Emily;Olenja Joyce;Lorway R. Robert;Anzala Anzala;Katie Viljoen;Jerome Wendoh;Elvis Kidzeru;Ulas Karaoz;Eoin Brodie;Gerrit Botha;Nicola Mulder;Clive Gray;William Cameron;Alain Stintzi;Heather Jaspan;Paul N. Levett;David Alexander;Naveed Gulzar;Prabvir S. Grewal;Art F. Y. Poon;Zabrina Brumme;P. Richard Harrigan;James I. Brooks;Paul A. Sandstrom;Stryker Calvez;Stephen E. Sanche;Jamie K. Scott;Leslie Swartz;Ashraf Kagee;Anthea Lesch;Zuhayr Kafaar;Anneliese De Wet;Evaezi Okpokoro;Sophia Osawe;Ruth Daitiri;Grace Choji;Stephen Umaru;Felicia Okolo;Pam Datong;Alash’le Abimiku;Janan Dietrich;Tricia Smith;Laura Cotton;Stefanie Hornschuh;Martin van der Watt;Cari L. Miller;Glenda Gray;Jenni Smit;Manjeetha Jaggernath;Thumbi Ndung’u;Mark Brockman;Angela Kaida;Maureen Akolo;Joshua Kimani;Larry Gelmon;Michael Chitwa;Justus Osero;Anne Cockcroft;Nobantu Marokoane;Leagajang Kgakole;Boikhutso Maswabi;Neo Mpofu;Umaira Ansari;Neil Andersson;Elizabeth Nakinobe;George Mukalazi Miiro;Flavia Zalwango;Jessica Nakiyingi-Miiro;Potiano Kaleebu;John Ross Semwanga;Emily Nyanzi;Saidat Namuli Musoke;Elizabeth Nakinobe;George Miiro;Edward Katongole Mbidde;Tom Lutalo;Pontiano Kaleebu;Ray Handema;Graham P. Chianzu;Moussa Thiam;Diabou Diagne-Gueye;Mame K. Ndiaye;Moustapha Mbow;Birahim P. Ndiaye;Ibrahima Traore;Mamadou C. Dia;Gilleh Thomas;Coumba Tour-Kane;Souleymane Mboup;Assan Jaye;Emily Nyanzi;Edward Katongole Mbidde;Pontiano Kaleebu;Juliet Mpendo;Joshua Kimani;Josephine Birungi;Winnie Muyindike;Andrew Kambugu;Hachizovu Sebastian;Handema Ray;Chaponda Mike;Kabuya Jean Bertin;Mulenga Modest;Moussa Thiam;Omar Janha;Alberta Davis;Alfred Amambua-Ngwa;Davis C. Nwakanma;Souleymane Mboup;Assan Jaye;Sanne Jespersen;Bo Langhoff Hønge;Joakim Esbjörnsson;Candida Medina;David Da Silva TÉ;Faustino Gomes Correira;Alex Lund Laursen;Lars Østergaard;Andreas Andersen;Peter Aaby;Christian Erikstrup;Christian Wejse;Siry Dieye;Moussa Sarr;Haby Sy;Helene D. Mbodj;Marianne Ndiaye;Amy Ndiaye;Seydi Moussa;Assan Jaye;Souleymane Mboup;Balthazar M. Nyombi;Elichilia R. Shao;Innocent B. Chilumba;Sikhulile Moyo;Simani Gaseitsiwe;Rosemary Musonda;Pam Datong;Bucky Inyang;Sophia Osawe;Abel Izang;Chundung Cole;Felicia Okolo;Bill Cameron;Kenneth Rosenthal;Clive Gray;Heather Jaspan;Alash’le Abimiku;Boitumelo Seraise;Kerstin Andrea-Marobela;Sikhulile Moyo;Rosemary Musonda;Joseph Makhema;Max Essex;Simani Gaseitsiwe
通讯作者：
Simani Gaseitsiwe

Rapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda

DOI：
10.1186/s12879-025-11271-0
发表时间：
2025-07-02
期刊：
BMC INFECTIOUS DISEASES
影响因子：
3.000
作者：
Andrew Nsawotebba;Susan Nabadda;Valeria Nakintu;Isaac Ssewanyana;Misaki Wayengera;Jonathan Kabazzi;Stephen Balinandi;Godfrey Pimundu;Tonny Muyigi;Alisen Ayitewala;Samuel Gidudu;Morgan Otita;Ibrahim Mugerwa;Moses Rubangakene;Sulaiman Ikoba;Sam Kalungi;Rhoda Wanyenze;Kevin K. Ariën;Eunice Namboozo;Benedict Kanamwanji;Steven Ssekyondwa;Ronald Kasujja;Derrick Kitwe;Catherine Dambya;Innocent Morunyanga;Reginald Rony Bahatungire;Francis Kakooza;Moses Joloba;Atek Kagirita;Allan Muruta;Pontiano Kaleebu;Henry Kyobe;Charles Olaro;Diana Atwine;Jane Ruth Aceng
通讯作者：
Jane Ruth Aceng

Chemokine-receptor genes and AIDS risk

趋化因子受体基因与艾滋病风险

DOI：
10.1038/417140a
发表时间：
2002-05-09
期刊：
NATURE
影响因子：
48.500
作者：
Patricia A. Ramaley;Neil French;Pontiano Kaleebu;Charles Gilks;James Whitworth;Adrian V. S. Hill
通讯作者：
Adrian V. S. Hill