TREATMENT OF MALIGNANT BRAIN TUMORS WITH INTERSTITIAL RADIOTHERAPY

目前大多数恶性成人脑肿瘤的治疗结果仍然存在 失望 尽管最积极的多模态治疗，中位数 最常见的肿瘤多形性胶质母细胞瘤的存活期为10个月 治愈方法只是传闻 这些肿瘤已经超出了外科手术的范围 常规外照射放射治疗的切除和总剂量是 受到周围正常大脑耐受性的限制。 通过放置放射性物质 碘125的种子直接进入肿瘤床，我们希望实现：1）a 对肿瘤的高辐射剂量; 2）对周围环境的低辐射剂量 正常脑;和3）通过递送的辐射增加治疗比率 在低剂量率下。

Results of current therapy of most malignant adult brain tumors remain disappointing. Despite the most aggressive multimodality treatment, median survival in the most common tumor, glioblastoma multiforme, is 10 months and cure is anecdotal. These tumors extend beyond the limits of surgical resection and total dose of conventional external beam radiotherapy is limited by surrounding normal brain tolerance. By placing radioactive seeds of Iodine 125 directly into the tumor bed we hope to achieve: 1) a high radiation dose to the tumor; 2) a low radiation dose to surrounding normal brain; and 3) increased therapeutic ratio with radiation delivered at low dose rates.