MECHANISMS OF ACUTE VASCULAR REACTION TO INJURY

该计划对大型和小型船舶的响应有共同的兴趣 以及它们的内皮细胞和平滑肌细胞对损伤的反应。 基本 人们提出的问题与可能存在的基本病理过程有关 参与动脉粥样硬化。 允许或刺激细胞的机制 复制、细胞迁移和细胞间相互作用 研究了 机械损伤和中毒损伤的潜在作用， 外源性物质的代谢产物和疱疹病毒 可能会在动物和人类身上产生增生性病变， 研究了 该计划包括研究的性质变化， 平滑肌倍性与年龄和高血压的研究。 机制 白细胞、内皮细胞、HDL载脂蛋白和 ApoSAA也正在接受调查。 正在使用各种方法 包括细胞培养、组织免疫细胞化学、流式细胞光度法， 扫描电子显微镜和病毒和淀粉样蛋白的分子探针 细胞中的蛋白质基因。

This program has a common interest in responses of large and small vessels and of their endothelial and smooth muscle cells to injury. Fundamental questions are being asked related to basic pathologic processes that may be involved in atherosclerosis. Mechanisms that permit or stimulate cell replication, cell migration and cellular interactions are being investigated. The potential role of mechanical and toxic injuries, of the metabolic products of xenobiotics and the mechanism whereby herpesviruses may produce proliferative lesions in animals and human beings are being investigated. The program includes studies of the nature of changes in ploidy of smooth muscle with age and hypertension studies. Mechanisms of interaction of leukocytes, endothelial cells, of the HDL apoprotein and ApoSAA are also being investigated. A wide range of methods are being used including cell culture, histoimmunocytochemistry, flow cytophotometry, scanning electron microscopy and molecular probes for viral and amyloid protein genes in cells.