ROLE OF THE ARTERIAL WALL IN ATHEROSCLEROSIS

动脉壁在动脉粥样硬化中的作用

• 批准号: 3097475
• 负责人: WILLIAM HOLLANDER
• 金额: $ 144.72万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-09-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3097475
• 关键词: atherosclerosis; hypertension; vascular smooth muscle

The major objectives of the project are to elucidate (1) the interactions of hypertension and lipoproteins in the pathogenesis of atherosclerosis; (2) the role of the smooth muscle cell and endothelial cell in vascular permeability and the biosynthesis of connective tissue proteins; (3) role of acid mucopolysaccharides and proteoglycans in atherosclerosis and their relationship to lipid, lipoprotein and calcium deposition in the plaque; (4) the role of platelets and the platelet "release action" in atherosclerosis; (5) role of physico-chemical changes of lipid and lipoproteins in atherosclerosis; (6) role of lipoprotein interactions with acid mucopolysaccharides, connective tissue proteins and calcium in atherosclerosis. The proposed programs will be carried out in subhuman primates (cynomolgus monkey) with experimental atherosclerosis and/or hypertension and in smooth muscle cells and endothelial cells grown in cell culture. These studies will focus on the correlations to the biochemical, metabolic and morphologic changes in the artery during the development and treatment of atherosclerotic and/or hypertensive vascular disease.

该项目的主要目标是阐明(1) 高血压和脂蛋白在动脉粥样硬化发病机制中的作用 血管通透性和血管内皮细胞在血管通透性中的作用 结缔组织蛋白的生物合成；(3)酸的作用 粘多糖和蛋白多糖与动脉粥样硬化的关系 对脂质、脂蛋白和钙在斑块中的沉积；(4)作用 血小板和血小板在动脉粥样硬化中的释放作用；(5) 脂类和脂蛋白在动脉粥样硬化中的物理化学变化 脂蛋白与酸性粘多糖、结缔组织的相互作用 蛋白质和钙与动脉粥样硬化。拟议的计划将得到实施 患有实验性动脉粥样硬化的亚人类灵长类动物(食蟹猴) 和/或高血压和血管内皮细胞 细胞培养。这些研究将集中在与生化的相关性上， 发育和发育过程中动脉的代谢和形态变化 动脉粥样硬化和/或高血压血管疾病的治疗。