Accelerating Discovery: New integrated approaches to uncover the brain’s regulation of body weight

加速发现：揭示大脑体重调节的新综合方法

• 批准号: MC_PC_15077
• 负责人: Philip Hannaford
• 金额: $ 57.34万
• 依托单位: University of Aberdeen
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_15077
• 关键词: Accelerating; Discovery; New; integrated; approaches

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，GtR 中尚未提供所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但可能是因为它包含个人详细信息等敏感信息。

项目成果

Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity.

雄性大鼠食欲和生长的发育程序会增加下丘脑血清素 (5-HT)5A 受体的表达和敏感性。

• DOI: 10.1038/s41366-020-0643-2
• 发表时间: 2020
• 期刊: International journal of obesity (2005)
• 作者: Wargent ET

5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.

• DOI: 10.1038/s41380-021-01220-z
• 发表时间: 2021-12
• 期刊: Molecular psychiatry
• 影响因子: 11
• 作者: He Y;Cai X;Liu H;Conde KM;Xu P;Li Y;Wang C;Yu M;He Y;Liu H;Liang C;Yang T;Yang Y;Yu K;Wang J;Zheng R;Liu F;Sun Z;Heisler L;Wu Q;Tong Q;Zhu C;Shu G;Xu Y
• 通讯作者: Xu Y

Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.

• DOI: 10.1016/j.molmet.2022.101665
• 发表时间: 2023-02
• 期刊: MOLECULAR METABOLISM
• 影响因子: 8.1
• 作者: Wagner, Stefan;Brierley, Daniel I.;Leeson-Payne, Alasdair;Jiang, Wanqing;Chianese, Raffaella;Lam, Brian Y. H.;Dowsett, Georgina K. C.;Cristiano, Claudia;Lyons, David;Reimann, Frank;Gribble, Fiona M.;de Morentin, Pablo B. Martinez;Yeo, Giles S. H.;Trapp, Stefan;Heisler, Lora K.
• 通讯作者: Heisler, Lora K.

Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N.

• DOI: 10.1038/s41598-018-33928-4
• 发表时间: 2018-10-23
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Dalby MJ;Aviello G;Ross AW;Walker AW;Barrett P;Morgan PJ
• 通讯作者: Morgan PJ

Lorcaserin improves glycemic control via a melanocortin neurocircuit.

• DOI: 10.1016/j.molmet.2017.07.004
• 发表时间: 2017-10
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: Burke LK;Ogunnowo-Bada E;Georgescu T;Cristiano C;de Morentin PBM;Valencia Torres L;D'Agostino G;Riches C;Heeley N;Ruan Y;Rubinstein M;Low MJ;Myers MG;Rochford JJ;Evans ML;Heisler LK
• 通讯作者: Heisler LK