Capital award for UK DRI at University of Edinburgh

爱丁堡大学英国 DRI 资本奖

• 批准号: MC_PC_17113
• 负责人: Giles Hardingham
• 金额: $ 593.27万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_17113
• 关键词: Capital; award; UK; DRI; University

Alongside significant co-investment from the University of Edinburgh, the expected outcome of this funding is the concluded expansion of facilities on 1st floor of the Chancellor Building at the Edinburgh Bioquarter Campus, to house a larger centre. Full occupancy is expected by October 2018.. Additionally, £2.5m for procurement of capital equipment is being provided to assist the UK DRI in implementing its first scientific programmes (funding provided separately).Together, the building and equipment will provide the location for, in the initial stages of 5 programmes initially, to grow significantly in number in subsequent years. The UK DRI as a whole will help to cement the UK’s world-leading position by also promoting innovate approaches and forging much closer collaboration and integration of on-going UK research efforts. The new institute has been established to lead the UK’s dementia research effort and forms a core part of achieving the Prime Minister’s Challenge on Dementia 2020.

除了爱丁堡大学的重大共同投资外，这笔资金的预期成果是完成爱丁堡生物区校园校长大楼一楼的设施扩建，以容纳更大的中心。预计将于2018年10月全面入住。此外，还将提供250万英镑用于采购资本设备，以协助英国DRI实施其第一批科学计划（资金单独提供）。在最初的5个计划的初始阶段，建筑和设备将为随后几年的数量大幅增长提供场所。英国DRI作为一个整体将有助于巩固英国的世界领先地位，也促进创新方法和锻造更密切的合作和整合正在进行的英国研究工作。新研究所的成立是为了领导英国的痴呆症研究工作，并成为实现首相2020年痴呆症挑战的核心部分。

项目成果

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

• DOI: 10.1038/s41467-021-27702-w
• 发表时间: 2022-01-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Jiwaji Z;Tiwari SS;Avilés-Reyes RX;Hooley M;Hampton D;Torvell M;Johnson DA;McQueen J;Baxter P;Sabari-Sankar K;Qiu J;He X;Fowler J;Febery J;Gregory J;Rose J;Tulloch J;Loan J;Story D;McDade K;Smith AM;Greer P;Ball M;Kind PC;Matthews PM;Smith C;Dando O;Spires-Jones TL;Johnson JA;Chandran S;Hardingham GE
• 通讯作者: Hardingham GE

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes.

• DOI: 10.1016/j.celrep.2021.108882
• 发表时间: 2021-03-23
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Baxter PS;Dando O;Emelianova K;He X;McKay S;Hardingham GE;Qiu J
• 通讯作者: Qiu J

Long-term plasticity of astrocytic phenotypes and their control by neurons in health and disease.

• DOI: 10.1042/ebc20220090
• 发表时间: 2023-03-03
• 期刊: Essays in biochemistry
• 影响因子: 6.4

Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage.

• DOI: 10.3390/biom12101438
• 发表时间: 2022-10-07
• 期刊: Biomolecules
• 影响因子: 5.5