Gut Reaction - The Health Data Research Hub for Inflammatory Bowel Disease

肠道反应 - 炎症性肠病健康数据研究中心

• 批准号: MC_PC_19003
• 负责人: John Bradley
• 金额: $ 611.05万
• 依托单位: Cambridge University Hospitals NHS Foundation Trust
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_19003
• 关键词: Gut; Reaction; Health; Data; Research

"Crohn's Disease and Ulcerative Colitis are the main forms of IBD. They cause debilitating symptoms affecting 0.78% of the UK population (500,0001 people), and costing UK health budgets approximately £1.5 Billion2 each year. Treatment is with steroids, immunosuppressants and antibody therapies, but results are variable. Over 70% of patients with Crohn’s and 15% with colitis require major surgery3. There is an urgent need to better understand why patients respond differently to treatments in order to improve outcomes and reduce costs.Recent advances in clinical imaging, pathology, and genomic technologies have produced remarkable progress in understanding IBD. However, the power of these technologies cannot be clinically realised until these data can be combined and used in a meaningful way.Our DIH will integrate data from multiple sources and create a secure research resource that allows approved researchers to access data, whilst protecting the privacy of individuals.Patient and public involvement is key to our success. 25,000 IBD patients have already provided consent for their health records to be retrieved and used for medical research. Working together, we will transform our understanding of IBD, drive improvements in diagnosis and treatment, and deliver a data framework to reproduce in other disease areas."

克罗恩病和溃疡性结肠炎是IBD的主要形式。它们引起的衰弱症状影响了0.78%的英国人口（500，0001人），每年花费英国卫生预算约15亿英镑2。治疗是用类固醇，免疫抑制剂和抗体疗法，但结果是可变的。超过70%的克罗恩病患者和15%的结肠炎患者需要进行大手术3。为了改善治疗效果和降低成本，我们迫切需要更好地了解为什么患者对治疗的反应不同。临床影像学、病理学和基因组技术的最新进展在理解IBD方面取得了显着进展。然而，这些技术的力量无法在临床上实现，除非这些数据可以以有意义的方式组合和使用。我们的DIH将整合来自多个来源的数据，并创建一个安全的研究资源，允许批准的研究人员访问数据，同时保护个人隐私。患者和公众的参与是我们成功的关键。25，000名IBD患者已经同意检索他们的健康记录并用于医学研究。通过共同努力，我们将改变我们对IBD的理解，推动诊断和治疗的改进，并提供一个数据框架，以在其他疾病领域重现。"

项目成果

COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control study.

• DOI: 10.1016/s2468-1253(22)00274-6
• 发表时间: 2022-11
• 期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY
• 影响因子: 35.7
• 作者: Alexander, James L.;Liu, Zhigang;Sandoval, Diana Munoz;Reynolds, Catherine;Ibraheim, Hajir;Anandabaskaran, Sulak;Saifuddin, Aamir;Seoane, Rocio Castro;Anand, Nikhil;Nice, Rachel;Bewshea, Claire;D'Mello, Andrea;Constable, Laura;Jones, Gareth R.;Balarajah, Sharmili;Fiorentino, Francesca;Sebastian, Shaji;Irving, Peter M.;Hicks, Lucy C.;Williams, Horace R. T.;Kent, Alexandra J.;Linger, Rachel;Parkes, Miles;Kok, Klaartje;Patel, Kamal V.;Teare, Julian P.;Altmann, Daniel M.;Goodhand, James R.;Hart, Ailsa L.;Lees, Charlie W.;Boyton, Rosemary J.;Kennedy, Nicholas A.;Ahmad, Tariq;Powell, Nick
• 通讯作者: Powell, Nick

The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn's Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation.

• DOI: 10.1093/ecco-jcc/jjaa220
• 发表时间: 2021-05-04
• 期刊: Journal of Crohn's & colitis
• 作者: Nelson A;Stewart CJ;Kennedy NA;Lodge JK;Tremelling M;UK IBD Genetics Consortium;Probert CS;Parkes M;Mansfield JC;Smith DL;Hold GL;Lees CW;Bridge SH;Lamb CA
• 通讯作者: Lamb CA

COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study.

• DOI: 10.1016/s2468-1253(22)00005-x
• 发表时间: 2022-04
• 期刊: The lancet. Gastroenterology & hepatology
• 作者: Alexander JL;Kennedy NA;Ibraheim H;Anandabaskaran S;Saifuddin A;Castro Seoane R;Liu Z;Nice R;Bewshea C;D'Mello A;Constable L;Jones GR;Balarajah S;Fiorentino F;Sebastian S;Irving PM;Hicks LC;Williams HRT;Kent AJ;Linger R;Parkes M;Kok K;Patel KV;Teare JP;Altmann DM;Boyton RJ;Goodhand JR;Hart AL;Lees CW;Ahmad T;Powell N;VIP study investigators
• 通讯作者: VIP study investigators