Programme 3: Early development and risk of adult musculoskeletal disease

项目 3：成人肌肉骨骼疾病的早期发育和风险

• 批准号: MC_PC_21003
• 负责人: Nicholas Harvey
• 金额: $ 230.5万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_21003
• 关键词: Programme; Early; development; risk; adult

The aim of this programme is to integrate observational epidemiology and mechanistic understanding to inform novel interventions in early life to reduce the risk of later diseases such as osteoporosis and sarcopenia. Whilst our results have already informed national guidelines (DH, NICE, Public Health England and the Scientific Advisory Committee on Nutrition), the programme will advance this work by generating discovery science to delineate underlying mechanisms and to establish the wider relevance of the findings in order to inform the successful implementation of resulting public health strategies.

该计划的目的是将观察流行病学和机械理解结合起来，为生命早期的新干预措施提供信息，以减少骨质疏松症和肌肉减少症等后期疾病的风险。虽然我们的研究结果已经为国家指导方针（卫生署，NICE，英国公共卫生和营养科学咨询委员会）提供了信息，但该计划将通过产生发现科学来推进这项工作，以描述潜在的机制，并建立更广泛的相关性，以便为成功实施由此产生的公共卫生战略提供信息。

项目成果

Altered H19/miR-675 expression in skeletal muscle is associated with low muscle mass in community-dwelling older adults

骨骼肌中 H19/miR-675 表达的改变与社区老年人的低肌肉质量有关

• DOI: 10.1002/rco2.44
• 发表时间: 2021
• 期刊: JCSM Rapid Communications
• 作者: Antoun E

Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation.

• DOI: 10.1177/1759720x211024029
• 发表时间: 2021
• 期刊: Therapeutic advances in musculoskeletal disease
• 影响因子: 4.2
• 作者: Aggarwal V;Maslen C;Abel RL;Bhattacharya P;Bromiley PA;Clark EM;Compston JE;Crabtree N;Gregory JS;Kariki EP;Harvey NC;Ward KA;Poole KES
• 通讯作者: Poole KES

DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake.

• DOI: 10.1080/15592294.2021.1908706
• 发表时间: 2022-04
• 期刊: Epigenetics
• 影响因子: 3.7
• 作者: Antoun E;Titcombe P;Dalrymple K;Kitaba NT;Barton SJ;Flynn A;Murray R;Garratt ES;Seed PT;White SL;Cooper C;Inskip HM;Hanson M;Poston L;Godfrey KM;Lillycrop KA;UPBEAT Consortium/EpiGen Consortium
• 通讯作者: UPBEAT Consortium/EpiGen Consortium

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.

• DOI: 10.1038/s41467-021-22639-6
• 发表时间: 2021-05-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Acton RJ;Yuan W;Gao F;Xia Y;Bourne E;Wozniak E;Bell J;Lillycrop K;Wang J;Dennison E;Harvey NC;Mein CA;Spector TD;Hysi PG;Cooper C;Bell CG
• 通讯作者: Bell CG

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit.

• DOI: 10.7554/elife.71094
• 发表时间: 2022-03-08
• 期刊: eLife
• 影响因子: 7.7
• 作者: Ashley B;Simner C;Manousopoulou A;Jenkinson C;Hey F;Frost JM;Rezwan FI;White CH;Lofthouse EM;Hyde E;Cooke LDF;Barton S;Mahon P;Curtis EM;Moon RJ;Crozier SR;Inskip HM;Godfrey KM;Holloway JW;Cooper C;Jones KS;Lewis RM;Hewison M;Garbis SDD;Branco MR;Harvey NC;Cleal JK
• 通讯作者: Cleal JK