GENERAL CLINICAL RESEARCH CENTER

该项目旨在运营一个3床临床研究中心， 为儿童提供多学科临床研究设施。 临床研究将由动物/基础研究补充。 控制正常和异常生长的内分泌机制， 探索使用新的激素测定方法。 婴儿及儿童 心肺问题将接受心脏评估的新方法 使用非侵入性和定量心血管造影技术。 研究 与定义遗传性结缔组织中的基本生化缺陷有关， 组织疾病将继续存在，并尝试纠正其中一些 应进行酶替代。 多学科研究 婴儿胃肠道吸收不良综合征的病理生理学， 孩子将被制造。 新的治疗方案，以纠正 儿童免疫缺陷病应当予以治疗。 正常和异常 将评估新生儿的行为模式。 的关系 三尖杉酯碱对极低出生体重儿呼吸窘迫的影响 将根据非现场协议进行评估 其他新治疗 风险投资将针对控制某些内分泌， 神经和心脏疾病。

The project is desinged to operate a 3-bed Clinical Research Center for Children with facilities for multi-disciplinary clinical investigations. The clinical studies will be supplemented by animal/basic research. Endocrine mechansims that control normal and abnormal growth will be explored using new hormone assay methods. Infants and children with cardiopulmonary problems will undergo new methods for cardiac evaluation using non-invasive and quantitative angiocardiographic techniques. Studies related to defining the basic biochemical defects in hereditable connective tissue disorders will be continued, and attempts to correct some of these through enzyme replacement shall be made. A multidisciplinary study of the pathophysiology in gastrointestinal malabsorption syndromes in infants and children shall be made. New therapeutic programs for the correction of immune deficiency disease in children shall be tried. Normal and abnormal behavior patterns in newborn infants will be evaluated. The relation of prostaglandins to respiratory distress of very low birth-weight infants will be assessed under an off-site protocol. Other new therapeutic ventures will be directed towards the control of certain endocrine, neurologic, and cardiac, disorders.